TY  - GEN
AB  - The parastrial nucleus (PS) is a lenticular formation located beneath the anterior commissure in the preoptic area. Anatomic and physiologic studies have demonstrated: 1) a direct projection from PS neurons to the dorsomedial hypothalamus (DMH), 2) increased cold-evoked Fos expression in PS, and 3) infected neurons in PS after injection of Pseudorabies virus into the interscapular brown adipose tissue (iBAT). However, it has not been assessed whether a specific population of PS neurons projecting to DMH is involved in the modulation of iBAT thermogenesis. We aim to determine if PS projecting neurons to DMH are selectively responsive to cold or warm stimuli, and if pharmacologic manipulation of these neurons activates iBAT thermogenesis.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AU  - Chiavetta, Pierfrancesco
AU  - Cano, Georgina
AU  - Hernan, Shelby
AU  - Stanzani, Agnese
AU  - Tupone, Domenico
DA  - 2020
DO  - 10.6083/8w32r630d
DO  - DOI
ID  - 8335
KW  - Dorsomedial Hypothalamic Nucleus
KW  - Body Temperature Regulation
KW  - Nucleus Raphe Pallidus
KW  - Adipose Tissue, Brown
KW  - ibat
KW  - thermoregulation
KW  - rpa
KW  - ps
KW  - dmh
L1  - https://digitalcollections.ohsu.edu/record/8335/files/ResearchWeek.2020.Chiavetta.Pierfrancesco.pdf
L2  - https://digitalcollections.ohsu.edu/record/8335/files/ResearchWeek.2020.Chiavetta.Pierfrancesco.pdf
L4  - https://digitalcollections.ohsu.edu/record/8335/files/ResearchWeek.2020.Chiavetta.Pierfrancesco.pdf
LK  - https://digitalcollections.ohsu.edu/record/8335/files/ResearchWeek.2020.Chiavetta.Pierfrancesco.pdf
N2  - The parastrial nucleus (PS) is a lenticular formation located beneath the anterior commissure in the preoptic area. Anatomic and physiologic studies have demonstrated: 1) a direct projection from PS neurons to the dorsomedial hypothalamus (DMH), 2) increased cold-evoked Fos expression in PS, and 3) infected neurons in PS after injection of Pseudorabies virus into the interscapular brown adipose tissue (iBAT). However, it has not been assessed whether a specific population of PS neurons projecting to DMH is involved in the modulation of iBAT thermogenesis. We aim to determine if PS projecting neurons to DMH are selectively responsive to cold or warm stimuli, and if pharmacologic manipulation of these neurons activates iBAT thermogenesis.
PB  - Oregon Health and Science University
PY  - 2020
T1  - A neural projection from the parastrial nucleus to the dorsomedial hypothalamus contributes to the activation of BAT thermogenesis
TI  - A neural projection from the parastrial nucleus to the dorsomedial hypothalamus contributes to the activation of BAT thermogenesis
UR  - https://digitalcollections.ohsu.edu/record/8335/files/ResearchWeek.2020.Chiavetta.Pierfrancesco.pdf
Y1  - 2020
ER  -