000008335 001__ 8335 000008335 005__ 20240125142325.0 000008335 0247_ $$2DOI$$a10.6083/8w32r630d 000008335 037__ $$aIR 000008335 245__ $$aA neural projection from the parastrial nucleus to the dorsomedial hypothalamus contributes to the activation of BAT thermogenesis 000008335 260__ $$bOregon Health and Science University 000008335 269__ $$a2020 000008335 336__ $$aAbstract 000008335 520__ $$aThe parastrial nucleus (PS) is a lenticular formation located beneath the anterior commissure in the preoptic area. Anatomic and physiologic studies have demonstrated: 1) a direct projection from PS neurons to the dorsomedial hypothalamus (DMH), 2) increased cold-evoked Fos expression in PS, and 3) infected neurons in PS after injection of Pseudorabies virus into the interscapular brown adipose tissue (iBAT). However, it has not been assessed whether a specific population of PS neurons projecting to DMH is involved in the modulation of iBAT thermogenesis. We aim to determine if PS projecting neurons to DMH are selectively responsive to cold or warm stimuli, and if pharmacologic manipulation of these neurons activates iBAT thermogenesis. 000008335 540__ $$fCC BY 000008335 542__ $$fIn copyright - joint owners 000008335 650__ $$aDorsomedial Hypothalamic Nucleus$$018030 000008335 650__ $$aBody Temperature Regulation$$015706 000008335 650__ $$aNucleus Raphe Pallidus$$040732 000008335 650__ $$aAdipose Tissue, Brown$$015865 000008335 6531_ $$aibat 000008335 6531_ $$athermoregulation 000008335 6531_ $$arpa 000008335 6531_ $$aps 000008335 6531_ $$admh 000008335 691__ $$aSchool of Medicine$$041369 000008335 692__ $$aDepartment of Neurological Surgery$$041430 000008335 7001_ $$aChiavetta, Pierfrancesco$$uOregon Health and Science University$$041354 000008335 7001_ $$aCano, Georgina$$uOregon Health and Science University$$041354 000008335 7001_ $$aHernan, Shelby$$uOregon Health and Science University$$041354 000008335 7001_ $$aStanzani, Agnese$$uOregon Health and Science University$$041354 000008335 7001_ $$aTupone, Domenico$$uOregon Health and Science University$$041354 000008335 711__ $$aResearch Week$$uOregon Health and Science University$$d2020 000008335 8564_ $$9ced9c0a0-f874-4c5a-835a-d3542c4ee0a2$$s45108$$uhttps://digitalcollections.ohsu.edu/record/8335/files/ResearchWeek.2020.Chiavetta.Pierfrancesco.pdf 000008335 905__ $$a/rest/prod/8w/32/r6/30/8w32r630d 000008335 980__ $$aResearch Week