TY  - GEN
N2  - Placental mitochondrial respiration is impacted by obesity, type 2 gestational diabetes (A2GDM), and fetal sex. The mechanism of metformin, a "GDM treatment," is unclear, but it may inhibit mitochondrial complex I, reducing "mitochondrial respiration and ATP production." As previous studies examined the effect of metformin on cytotrophoblast but not syncytiotrophoblast (STB) we studied the effect on mitochondrial respiration in both male and female STB.
DO  - 10.6083/bg257f61t
DO  - DOI
AB  - Placental mitochondrial respiration is impacted by obesity, type 2 gestational diabetes (A2GDM), and fetal sex. The mechanism of metformin, a "GDM treatment," is unclear, but it may inhibit mitochondrial complex I, reducing "mitochondrial respiration and ATP production." As previous studies examined the effect of metformin on cytotrophoblast but not syncytiotrophoblast (STB) we studied the effect on mitochondrial respiration in both male and female STB.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Metformin impacts syncytiotrophoblast mitochondrial function in a sexually dimorphic manner
DA  - 2020
AU  - Hebert, Jessica
AU  - Myatt, Leslie
L1  - https://digitalcollections.ohsu.edu/record/8339/files/ResearchWeek.2020.Hebert.Jessica.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8339
L4  - https://digitalcollections.ohsu.edu/record/8339/files/ResearchWeek.2020.Hebert.Jessica.pdf
KW  - Diabetes, Gestational
KW  - Metformin
KW  - Mitochondria
KW  - Placenta
KW  - Diabetes Mellitus, Type 2
KW  - Pregnancy
KW  - Obesity
KW  - Fetal Development
KW  - Sex Characteristics
KW  - mitochondrial respiration
KW  - a2gdm
TI  - Metformin impacts syncytiotrophoblast mitochondrial function in a sexually dimorphic manner
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8339/files/ResearchWeek.2020.Hebert.Jessica.pdf
LK  - https://digitalcollections.ohsu.edu/record/8339/files/ResearchWeek.2020.Hebert.Jessica.pdf
UR  - https://digitalcollections.ohsu.edu/record/8339/files/ResearchWeek.2020.Hebert.Jessica.pdf
ER  -