000008339 001__ 8339
000008339 005__ 20240412103222.0
000008339 0247_ $$2DOI$$a10.6083/bg257f61t
000008339 037__ $$aIR
000008339 041__ $$aeng
000008339 245__ $$aMetformin impacts syncytiotrophoblast mitochondrial function in a sexually dimorphic manner
000008339 260__ $$bOregon Health and Science University
000008339 269__ $$a2020
000008339 336__ $$aAbstract
000008339 520__ $$aPlacental mitochondrial respiration is impacted by obesity, type 2 gestational diabetes (A2GDM), and fetal sex. The mechanism of metformin, a "GDM treatment," is unclear, but it may inhibit mitochondrial complex I, reducing "mitochondrial respiration and ATP production." As previous studies examined the effect of metformin on cytotrophoblast but not syncytiotrophoblast (STB) we studied the effect on mitochondrial respiration in both male and female STB.
000008339 540__ $$fCC BY
000008339 542__ $$fIn copyright - joint owners
000008339 650__ $$aDiabetes, Gestational$$029281
000008339 650__ $$aMetformin$$022128
000008339 650__ $$aMitochondria$$022348
000008339 650__ $$aPlacenta$$024210
000008339 650__ $$aDiabetes Mellitus, Type 2$$017675
000008339 650__ $$aPregnancy$$024523
000008339 650__ $$aObesity$$023118
000008339 650__ $$aFetal Development$$035918
000008339 650__ $$aSex Characteristics$$025917
000008339 6531_ $$amitochondrial respiration
000008339 6531_ $$aa2gdm
000008339 691__ $$aSchool of Medicine$$041369
000008339 692__ $$aDepartment of Obstetrics and Gynecology$$041432
000008339 7001_ $$aHebert, Jessica$$uOregon Health and Science University$$041354
000008339 7001_ $$aMyatt, Leslie$$uOregon Health and Science University$$041354
000008339 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008339 8564_ $$92daec17e-d216-43d3-bb85-dce75bf3af96$$s47532$$uhttps://digitalcollections.ohsu.edu/record/8339/files/ResearchWeek.2020.Hebert.Jessica.pdf
000008339 905__ $$a/rest/prod/bg/25/7f/61/bg257f61t
000008339 980__ $$aResearch Week