TY  - GEN
N2  - Wnt/beta-catenin signaling is critically important during development and for stem cell maintenance. Dysregulation of the Wnt pathway is implicated in numerous diseases, most notably cancer. Appropriate manipulations for intervention and therapy require an accurate understanding of the Wnt signaling mechanism. The consensus model for the Wnt pathway is surprisingly straightforward: In the OFF state of the pathway, the central regulator in the pathway, termed the destruction complex (DC) targets beta-catenin for degradation, thereby preventing it from nuclear signaling. In the ON state, ligand activation of the Wnt receptor inhibits DC activity, leading to beta-catenin accumulation and transcription of Wnt target genes.
DO  - 10.6083/xp68kg99h
DO  - DOI
AB  - Wnt/beta-catenin signaling is critically important during development and for stem cell maintenance. Dysregulation of the Wnt pathway is implicated in numerous diseases, most notably cancer. Appropriate manipulations for intervention and therapy require an accurate understanding of the Wnt signaling mechanism. The consensus model for the Wnt pathway is surprisingly straightforward: In the OFF state of the pathway, the central regulator in the pathway, termed the destruction complex (DC) targets beta-catenin for degradation, thereby preventing it from nuclear signaling. In the ON state, ligand activation of the Wnt receptor inhibits DC activity, leading to beta-catenin accumulation and transcription of Wnt target genes.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Evidence for discontinuous cyclical Wnt/beta-catenin signaling
DA  - 2020
AU  - Wehrli, Marcel
AU  - Petshow, Samuel
AU  - Hansen, Kevin
L1  - https://digitalcollections.ohsu.edu/record/8347/files/ResearchWeek.2020.Wehrli.Marcel.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8347
L4  - https://digitalcollections.ohsu.edu/record/8347/files/ResearchWeek.2020.Wehrli.Marcel.pdf
KW  - wnt signaling mechanism
KW  - disease development
KW  - bimolecular fluorescence complementation
KW  - stem cells
TI  - Evidence for discontinuous cyclical Wnt/beta-catenin signaling
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8347/files/ResearchWeek.2020.Wehrli.Marcel.pdf
LK  - https://digitalcollections.ohsu.edu/record/8347/files/ResearchWeek.2020.Wehrli.Marcel.pdf
UR  - https://digitalcollections.ohsu.edu/record/8347/files/ResearchWeek.2020.Wehrli.Marcel.pdf
ER  -