000008347 001__ 8347
000008347 005__ 20240405143501.0
000008347 0247_ $$2DOI$$a10.6083/xp68kg99h
000008347 037__ $$aIR
000008347 245__ $$aEvidence for discontinuous cyclical Wnt/beta-catenin signaling
000008347 260__ $$bOregon Health and Science University
000008347 269__ $$a2020
000008347 336__ $$aAbstract
000008347 520__ $$aWnt/beta-catenin signaling is critically important during development and for stem cell maintenance. Dysregulation of the Wnt pathway is implicated in numerous diseases, most notably cancer. Appropriate manipulations for intervention and therapy require an accurate understanding of the Wnt signaling mechanism. The consensus model for the Wnt pathway is surprisingly straightforward: In the OFF state of the pathway, the central regulator in the pathway, termed the destruction complex (DC) targets beta-catenin for degradation, thereby preventing it from nuclear signaling. In the ON state, ligand activation of the Wnt receptor inhibits DC activity, leading to beta-catenin accumulation and transcription of Wnt target genes.
000008347 540__ $$fCC BY
000008347 542__ $$fIn copyright - joint owners
000008347 6531_ $$awnt signaling mechanism
000008347 6531_ $$adisease development
000008347 6531_ $$abimolecular fluorescence complementation
000008347 6531_ $$astem cells
000008347 691__ $$aSchool of Medicine$$041369
000008347 692__ $$aDepartment of Integrative Biomedical and Diagnostic Sciences$$041418
000008347 7001_ $$aWehrli, Marcel$$uOregon Health and Science University
000008347 7001_ $$aPetshow, Samuel$$uOregon Health and Science University$$041354
000008347 7001_ $$aHansen, Kevin$$uOregon Health and Science University$$041354
000008347 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008347 8564_ $$9f0faa482-3dac-4c8e-ab99-dc1f0f20e7df$$s41740$$uhttps://digitalcollections.ohsu.edu/record/8347/files/ResearchWeek.2020.Wehrli.Marcel.pdf
000008347 905__ $$a/rest/prod/xp/68/kg/99/xp68kg99h
000008347 980__ $$aResearch Week