TY  - GEN
N2  - Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there are currently no treatments to slow, halt, or reverse the disease process. The disease is defined by the accumulation of the protein alpha-synuclein into aggregates known as Lewy inclusions, but how these aggregates initiate and propagate to various locations throughout the brain is unknown. To develop targeted disease modifying therapies, it is important to understand how aggregated forms of alpha-synuclein are transported throughout the nervous system and to determine the effect aggregation of alpha-synuclein has on specific cell types and specific behaviors. The hypotheses of this research are that alpha-synuclein aggregates propagate through neuroanatomically connected pathways and that induction of Lewy pathology results in behavioral deficits.
DO  - 10.6083/4f16c363r
DO  - DOI
AB  - Parkinson's disease (PD) is a progressive neurodegenerative disorder for which there are currently no treatments to slow, halt, or reverse the disease process. The disease is defined by the accumulation of the protein alpha-synuclein into aggregates known as Lewy inclusions, but how these aggregates initiate and propagate to various locations throughout the brain is unknown. To develop targeted disease modifying therapies, it is important to understand how aggregated forms of alpha-synuclein are transported throughout the nervous system and to determine the effect aggregation of alpha-synuclein has on specific cell types and specific behaviors. The hypotheses of this research are that alpha-synuclein aggregates propagate through neuroanatomically connected pathways and that induction of Lewy pathology results in behavioral deficits.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Transport of alpha-synuclein fibril aggregates in an in vivo mouse model of Parkinson's disease
DA  - 2020
AU  - Schaser, Allison
AU  - Stackhouse, Teresa
AU  - Meshul, Charlie
AU  - Lopez, Claudia S.
AU  - Unni, Vivek
L1  - https://digitalcollections.ohsu.edu/record/8350/files/ResearchWeek.2020.Schaser.Allison.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8350
L4  - https://digitalcollections.ohsu.edu/record/8350/files/ResearchWeek.2020.Schaser.Allison.pdf
KW  - Parkinson Disease
KW  - Neurodegenerative Diseases
KW  - alpha-Synuclein
KW  - Central Nervous System Diseases
KW  - Parkinsonian Disorders
KW  - Synucleinopathies
KW  - neurodegeneration
TI  - Transport of alpha-synuclein fibril aggregates in an in vivo mouse model of Parkinson's disease
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8350/files/ResearchWeek.2020.Schaser.Allison.pdf
LK  - https://digitalcollections.ohsu.edu/record/8350/files/ResearchWeek.2020.Schaser.Allison.pdf
UR  - https://digitalcollections.ohsu.edu/record/8350/files/ResearchWeek.2020.Schaser.Allison.pdf
ER  -