000008350 001__ 8350
000008350 005__ 20240418104711.0
000008350 0247_ $$2DOI$$a10.6083/4f16c363r
000008350 037__ $$aIR
000008350 245__ $$aTransport of alpha-synuclein fibril aggregates in an in vivo mouse model of Parkinson's disease
000008350 260__ $$bOregon Health and Science University
000008350 269__ $$a2020
000008350 336__ $$aAbstract
000008350 520__ $$aParkinson's disease (PD) is a progressive neurodegenerative disorder for which there are currently no treatments to slow, halt, or reverse the disease process. The disease is defined by the accumulation of the protein alpha-synuclein into aggregates known as Lewy inclusions, but how these aggregates initiate and propagate to various locations throughout the brain is unknown. To develop targeted disease modifying therapies, it is important to understand how aggregated forms of alpha-synuclein are transported throughout the nervous system and to determine the effect aggregation of alpha-synuclein has on specific cell types and specific behaviors. The hypotheses of this research are that alpha-synuclein aggregates propagate through neuroanatomically connected pathways and that induction of Lewy pathology results in behavioral deficits.
000008350 540__ $$fCC BY
000008350 542__ $$fIn copyright - joint owners
000008350 650__ $$aParkinson Disease$$023617
000008350 650__ $$aNeurodegenerative Diseases$$031750
000008350 650__ $$aalpha-Synuclein$$037032
000008350 650__ $$aCentral Nervous System Diseases$$016315
000008350 650__ $$aParkinsonian Disorders$$032648
000008350 650__ $$aSynucleinopathies$$013171
000008350 6531_ $$aneurodegeneration
000008350 691__ $$aSchool of Medicine$$041369
000008350 692__ $$aDepartment of Neurology$$041431
000008350 692__ $$aJungers Center for Neurosciences Research$$041475
000008350 7001_ $$aSchaser, Allison$$uOregon Health and Science University$$041354
000008350 7001_ $$aStackhouse, Teresa$$uOregon Health and Science University$$041354
000008350 7001_ $$aMeshul, Charlie$$uOregon Health and Science University$$041354
000008350 7001_ $$aLopez, Claudia S.$$uOregon Health and Science University$$041354
000008350 7001_ $$aUnni, Vivek$$uOregon Health and Science University$$041354
000008350 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008350 8564_ $$997a99363-628a-42a9-ae3d-c9f3f02a0972$$s44429$$uhttps://digitalcollections.ohsu.edu/record/8350/files/ResearchWeek.2020.Schaser.Allison.pdf
000008350 905__ $$a/rest/prod/4f/16/c3/63/4f16c363r
000008350 980__ $$aResearch Week