TY  - GEN
N2  - Sleep deprivation studies indicate an essential role for sleep in the pathophysiology of many conditions, with sleep at a lifetime maximum during early life. Previous research in our lab using an early life sleep disruption (ELSD) paradigm has shown long lasting deficits in complex social and cognitive behaviors in adult prairie voles. We hypothesized that increased time spent awake during ELSD may cause a transient increase in excitatory neurotransmission, leading to morphological changes in dendritic spines and long lasting changes in excitatory neurotransmission
DO  - 10.6083/rf55z832m
DO  - DOI
AB  - Sleep deprivation studies indicate an essential role for sleep in the pathophysiology of many conditions, with sleep at a lifetime maximum during early life. Previous research in our lab using an early life sleep disruption (ELSD) paradigm has shown long lasting deficits in complex social and cognitive behaviors in adult prairie voles. We hypothesized that increased time spent awake during ELSD may cause a transient increase in excitatory neurotransmission, leading to morphological changes in dendritic spines and long lasting changes in excitatory neurotransmission
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Dendritic spine morphology and excitatory neurotransmission in prefrontal cortex is altered after early life sleep disruption
DA  - 2020
AU  - Olson, Randall
AU  - Jones, Carolyn E.
AU  - Chau, Alex Q.
AU  - Puranik, Niyati
AU  - Moore, Cynthia
AU  - Wickham, Peyton T.
AU  - Meshul, Charles K.
AU  - Lim, Miranda M.
L1  - https://digitalcollections.ohsu.edu/record/8365/files/ResearchWeek.2020.Olson.Randall.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8365
L4  - https://digitalcollections.ohsu.edu/record/8365/files/ResearchWeek.2020.Olson.Randall.pdf
KW  - Sleep Deprivation
KW  - early life sleep disruption
KW  - sleep health
KW  - sleep disruption
KW  - prairie voles
KW  - dendritic spikes
KW  - cognitive behaviors
KW  - excitatory neurotransmission
TI  - Dendritic spine morphology and excitatory neurotransmission in prefrontal cortex is altered after early life sleep disruption
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8365/files/ResearchWeek.2020.Olson.Randall.pdf
LK  - https://digitalcollections.ohsu.edu/record/8365/files/ResearchWeek.2020.Olson.Randall.pdf
UR  - https://digitalcollections.ohsu.edu/record/8365/files/ResearchWeek.2020.Olson.Randall.pdf
ER  -