000008365 001__ 8365
000008365 005__ 20240329153623.0
000008365 0247_ $$2DOI$$a10.6083/rf55z832m
000008365 037__ $$aIR
000008365 245__ $$aDendritic spine morphology and excitatory neurotransmission in prefrontal cortex is altered after early life sleep disruption
000008365 260__ $$bOregon Health and Science University
000008365 269__ $$a2020
000008365 336__ $$aAbstract
000008365 520__ $$aSleep deprivation studies indicate an essential role for sleep in the pathophysiology of many conditions, with sleep at a lifetime maximum during early life. Previous research in our lab using an early life sleep disruption (ELSD) paradigm has shown long lasting deficits in complex social and cognitive behaviors in adult prairie voles. We hypothesized that increased time spent awake during ELSD may cause a transient increase in excitatory neurotransmission, leading to morphological changes in dendritic spines and long lasting changes in excitatory neurotransmission
000008365 540__ $$fCC BY
000008365 542__ $$fIn copyright - joint owners
000008365 650__ $$aSleep Deprivation$$026068
000008365 6531_ $$aearly life sleep disruption
000008365 6531_ $$asleep health
000008365 6531_ $$asleep disruption
000008365 6531_ $$aprairie voles
000008365 6531_ $$adendritic spikes
000008365 6531_ $$acognitive behaviors
000008365 6531_ $$aexcitatory neurotransmission
000008365 691__ $$aSchool of Medicine$$041369
000008365 692__ $$aDepartment of Behavioral Neuroscience$$041394
000008365 7001_ $$aOlson, Randall$$uOregon Health and Science University$$041354
000008365 7001_ $$aJones, Carolyn E.$$uOregon Health and Science University$$041354
000008365 7001_ $$aChau, Alex Q.$$uOregon Health and Science University$$041354
000008365 7001_ $$aPuranik, Niyati$$uOregon Health and Science University$$041354
000008365 7001_ $$aMoore, Cynthia$$uOregon Health and Science University$$041354
000008365 7001_ $$aWickham, Peyton T.$$uOregon Health and Science University$$041354
000008365 7001_ $$aMeshul, Charles K.$$uOregon Health and Science University$$041354
000008365 7001_ $$aLim, Miranda M.$$uOregon Health and Science University$$041354
000008365 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008365 8564_ $$91e7832c0-efee-4506-9229-436599a1e966$$s44150$$uhttps://digitalcollections.ohsu.edu/record/8365/files/ResearchWeek.2020.Olson.Randall.pdf
000008365 905__ $$a/rest/prod/rf/55/z8/32/rf55z832m
000008365 980__ $$aResearch Week