@article{IR,
      author = {Tang, Anita and Brandes, M.S. and Zweig, J.A. and Gray,  N.E.},
      url = {http://digitalcollections.ohsu.edu/record/8374},
      title = {NRF2 activating dimethyl fumarate improves mitochondrial  function, reduces oxidative stress and enhances synaptic  plasticity a neuronal model of synucleinopathy},
      publisher = {Oregon Health and Science University},
      abstract = {Lewy bodies comprised of aggregated alpha synuclein  (αSyn) protein are a pathological hallmark of the  Parkinson's disease (PD). Increased oxidative stress,  mitochondrial dysfunction and synaptic loss are also  features of the PD brain. NRF2 regulates the antioxidant  response pathway and has been shown to be neuroprotective  in many models of neurodegenerative diseases. Dimethyl  fumarate (DMF) is a NRF2 activator that is FDA approved for  treatment of multiple sclerosis making it an attractive  candidate to be repurpose for use in PD. Here we  investigate the antioxidant, mitochondrial and synaptic  effects of DMF in neurons isolated from the A53T αSyn  mouse model of synucleinopathy.},
      number = {IR},
      doi = {https://doi.org/10.6083/xk81jm03c},
      recid = {8374},
      address = {2020},
}