TY  - GEN
N2  - Lewy bodies comprised of aggregated alpha synuclein (αSyn) protein are a pathological hallmark of the Parkinson's disease (PD). Increased oxidative stress, mitochondrial dysfunction and synaptic loss are also features of the PD brain. NRF2 regulates the antioxidant response pathway and has been shown to be neuroprotective in many models of neurodegenerative diseases. Dimethyl fumarate (DMF) is a NRF2 activator that is FDA approved for treatment of multiple sclerosis making it an attractive candidate to be repurpose for use in PD. Here we investigate the antioxidant, mitochondrial and synaptic effects of DMF in neurons isolated from the A53T αSyn mouse model of synucleinopathy.
DO  - 10.6083/xk81jm03c
DO  - DOI
AB  - Lewy bodies comprised of aggregated alpha synuclein (αSyn) protein are a pathological hallmark of the Parkinson's disease (PD). Increased oxidative stress, mitochondrial dysfunction and synaptic loss are also features of the PD brain. NRF2 regulates the antioxidant response pathway and has been shown to be neuroprotective in many models of neurodegenerative diseases. Dimethyl fumarate (DMF) is a NRF2 activator that is FDA approved for treatment of multiple sclerosis making it an attractive candidate to be repurpose for use in PD. Here we investigate the antioxidant, mitochondrial and synaptic effects of DMF in neurons isolated from the A53T αSyn mouse model of synucleinopathy.
AD  - Portland State University
AD  - Portland State University
AD  - Portland State University
AD  - Portland State University
T1  - NRF2 activating dimethyl fumarate improves mitochondrial function, reduces oxidative stress and enhances synaptic plasticity a neuronal model of synucleinopathy
DA  - 2020
AU  - Tang, Anita
AU  - Brandes, M.S.
AU  - Zweig, J.A.
AU  - Gray, N.E.
L1  - https://digitalcollections.ohsu.edu/record/8374/files/ResearchWeek.2020.Tang.Anita.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8374
L4  - https://digitalcollections.ohsu.edu/record/8374/files/ResearchWeek.2020.Tang.Anita.pdf
KW  - Parkinson Disease
KW  - Lewy Bodies
KW  - Neurodegenerative Diseases
KW  - Oxidative Stress
KW  - Dimethyl Fumarate
KW  - alpha-Synuclein
KW  - Antioxidants
KW  - NRF2
KW  - synaptic density
KW  - mitochondrial function
TI  - NRF2 activating dimethyl fumarate improves mitochondrial function, reduces oxidative stress and enhances synaptic plasticity a neuronal model of synucleinopathy
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8374/files/ResearchWeek.2020.Tang.Anita.pdf
LK  - https://digitalcollections.ohsu.edu/record/8374/files/ResearchWeek.2020.Tang.Anita.pdf
UR  - https://digitalcollections.ohsu.edu/record/8374/files/ResearchWeek.2020.Tang.Anita.pdf
ER  -