000008374 001__ 8374
000008374 005__ 20240412160329.0
000008374 0247_ $$2DOI$$a10.6083/xk81jm03c
000008374 037__ $$aIR
000008374 041__ $$aeng
000008374 245__ $$aNRF2 activating dimethyl fumarate improves mitochondrial function, reduces oxidative stress and enhances synaptic plasticity a neuronal model of synucleinopathy
000008374 260__ $$bOregon Health and Science University
000008374 269__ $$a2020
000008374 336__ $$aAbstract
000008374 520__ $$aLewy bodies comprised of aggregated alpha synuclein (αSyn) protein are a pathological hallmark of the Parkinson's disease (PD). Increased oxidative stress, mitochondrial dysfunction and synaptic loss are also features of the PD brain. NRF2 regulates the antioxidant response pathway and has been shown to be neuroprotective in many models of neurodegenerative diseases. Dimethyl fumarate (DMF) is a NRF2 activator that is FDA approved for treatment of multiple sclerosis making it an attractive candidate to be repurpose for use in PD. Here we investigate the antioxidant, mitochondrial and synaptic effects of DMF in neurons isolated from the A53T αSyn mouse model of synucleinopathy.
000008374 540__ $$fCC BY
000008374 542__ $$fIn copyright - joint owners
000008374 650__ $$aParkinson Disease$$023617
000008374 650__ $$aLewy Bodies$$029273
000008374 650__ $$aNeurodegenerative Diseases$$031750
000008374 650__ $$aOxidative Stress$$030758
000008374 650__ $$aDimethyl Fumarate$$011420
000008374 650__ $$aalpha-Synuclein$$037032
000008374 650__ $$aAntioxidants$$014915
000008374 6531_ $$aNRF2
000008374 6531_ $$asynaptic density
000008374 6531_ $$amitochondrial function
000008374 7001_ $$aTang, Anita$$uPortland State University$$041357
000008374 7001_ $$aBrandes, M.S.$$uPortland State University$$041357
000008374 7001_ $$aZweig, J.A.$$uPortland State University$$041357
000008374 7001_ $$aGray, N.E.$$uPortland State University$$041357
000008374 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008374 8564_ $$923d86c89-bd73-448e-9b87-9c20aefd6254$$s42361$$uhttps://digitalcollections.ohsu.edu/record/8374/files/ResearchWeek.2020.Tang.Anita.pdf
000008374 905__ $$a/rest/prod/xk/81/jm/03/xk81jm03c
000008374 980__ $$aResearch Week