TY  - GEN
N2  - Headaches are frequently reported by patients with traumatic brain injury (TBI). The relationship between TBI and headaches is poorly understood. Disruption of the glymphatic pathway, a brain-wide network of perivascular spaces, could explain this link. The glymphatic pathway allows the exchange of fluid, solutes, and wastes between the cerebrospinal fluid and the brain interstitium. MRI-visible enlarged perivascular spaces (ePVS) may be putative surrogates of glymphatic function. The purpose of this study is to: a) characterize the ePVS burden in a cohort of healthy adolescents; b) determine if ePVS burden is increased in individuals with post-concussive symptoms.
DO  - 10.6083/9w032363r
DO  - DOI
AB  - Headaches are frequently reported by patients with traumatic brain injury (TBI). The relationship between TBI and headaches is poorly understood. Disruption of the glymphatic pathway, a brain-wide network of perivascular spaces, could explain this link. The glymphatic pathway allows the exchange of fluid, solutes, and wastes between the cerebrospinal fluid and the brain interstitium. MRI-visible enlarged perivascular spaces (ePVS) may be putative surrogates of glymphatic function. The purpose of this study is to: a) characterize the ePVS burden in a cohort of healthy adolescents; b) determine if ePVS burden is increased in individuals with post-concussive symptoms.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Linking traumatic brain injury, and post-traumatic headache: a potential role for glymphatic pathway dysfunction
DA  - 2020
AU  - Centeno, Luis D.L.
AU  - Luther, Madison
AU  - Nagel, Bonnie
AU  - Schwartz, Daniel
AU  - Newgard, Craig
AU  - Piantino, Juan
L1  - https://digitalcollections.ohsu.edu/record/8376/files/ResearchWeek.2020.Centeno.Luis.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8376
L4  - https://digitalcollections.ohsu.edu/record/8376/files/ResearchWeek.2020.Centeno.Luis.pdf
KW  - Magnetic Resonance Imaging
KW  - Brain Concussion
KW  - Headache
KW  - Glymphatic System
KW  - pediatrics
KW  - traumatic brain injury
KW  - MRI
KW  - enlarged perivascular spaces
TI  - Linking traumatic brain injury, and post-traumatic headache: a potential role for glymphatic pathway dysfunction
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8376/files/ResearchWeek.2020.Centeno.Luis.pdf
LK  - https://digitalcollections.ohsu.edu/record/8376/files/ResearchWeek.2020.Centeno.Luis.pdf
UR  - https://digitalcollections.ohsu.edu/record/8376/files/ResearchWeek.2020.Centeno.Luis.pdf
ER  -