TY - GEN AB - Radiation therapy is commonly employed in cancer treatment regimens in concert with other treatments but is rarely effective as a monotherapy. Radiation can be enhanced by the application of small molecule checkpoint inhibitors. These drugs are hydrophobic, necessitating a drug delivery agent, such as a polymer. This approach has been applied to breast and ovarian cancer, but has not yet been explored in colorectal. AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Landry, Madeleine AU - DuRoss, Allison N. AU - Neufeld, Megan J. AU - Hahn, Lukas AU - Sahay, Gaurav AU - Luxenhofer, Robert AU - Sun, Conroy DA - 2020 DO - 10.6083/79407x96w DO - DOI ID - 8399 KW - Radiation KW - Immunotherapy KW - Colonic Neoplasms KW - Immune Checkpoint Inhibitors KW - PARP/PI3K KW - polymeric nanoparticles KW - colon cancer L1 - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf L2 - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf L4 - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf N2 - Radiation therapy is commonly employed in cancer treatment regimens in concert with other treatments but is rarely effective as a monotherapy. Radiation can be enhanced by the application of small molecule checkpoint inhibitors. These drugs are hydrophobic, necessitating a drug delivery agent, such as a polymer. This approach has been applied to breast and ovarian cancer, but has not yet been explored in colorectal. PB - Oregon Health and Science University PY - 2020 T1 - Novel poly (2-oxazoline) micelle formulation of PARP/PI3K induces immunogenic cell death, enhancing response to triple combination therapy TI - Novel poly (2-oxazoline) micelle formulation of PARP/PI3K induces immunogenic cell death, enhancing response to triple combination therapy UR - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf Y1 - 2020 ER -