TY  - GEN
N2  - Radiation therapy is commonly employed in cancer treatment regimens in concert with other treatments but is rarely effective as a monotherapy. Radiation can be enhanced by the application of small molecule checkpoint inhibitors. These drugs are hydrophobic, necessitating a drug delivery agent, such as a polymer. This approach has been applied to breast and ovarian cancer, but has not yet been explored in colorectal.
DO  - 10.6083/79407x96w
DO  - DOI
AB  - Radiation therapy is commonly employed in cancer treatment regimens in concert with other treatments but is rarely effective as a monotherapy. Radiation can be enhanced by the application of small molecule checkpoint inhibitors. These drugs are hydrophobic, necessitating a drug delivery agent, such as a polymer. This approach has been applied to breast and ovarian cancer, but has not yet been explored in colorectal.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Novel poly (2-oxazoline) micelle formulation of PARP/PI3K induces immunogenic cell death, enhancing response to triple combination therapy
DA  - 2020
AU  - Landry, Madeleine
AU  - DuRoss, Allison N.
AU  - Neufeld, Megan J.
AU  - Hahn, Lukas
AU  - Sahay, Gaurav
AU  - Luxenhofer, Robert
AU  - Sun, Conroy
L1  - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8399
L4  - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf
KW  - Radiation
KW  - Immunotherapy
KW  - Colonic Neoplasms
KW  - Immune Checkpoint Inhibitors
KW  - PARP/PI3K
KW  - polymeric nanoparticles
KW  - colon cancer
TI  - Novel poly (2-oxazoline) micelle formulation of PARP/PI3K induces immunogenic cell death, enhancing response to triple combination therapy
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf
LK  - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf
UR  - https://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf
ER  -