000008399 001__ 8399
000008399 005__ 20240412154150.0
000008399 0247_ $$2DOI$$a10.6083/79407x96w
000008399 037__ $$aIR
000008399 041__ $$aeng
000008399 245__ $$aNovel poly (2-oxazoline) micelle formulation of PARP/PI3K induces immunogenic cell death, enhancing response to triple combination therapy
000008399 260__ $$bOregon Health and Science University
000008399 269__ $$a2020
000008399 336__ $$aAbstract
000008399 520__ $$aRadiation therapy is commonly employed in cancer treatment regimens in concert with other treatments but is rarely effective as a monotherapy. Radiation can be enhanced by the application of small molecule checkpoint inhibitors. These drugs are hydrophobic, necessitating a drug delivery agent, such as a polymer. This approach has been applied to breast and ovarian cancer, but has not yet been explored in colorectal.
000008399 540__ $$fCC BY
000008399 542__ $$fIn copyright - joint owners
000008399 650__ $$aRadiation$$025066
000008399 650__ $$aImmunotherapy$$020724
000008399 650__ $$aColonic Neoplasms$$016905
000008399 650__ $$aImmune Checkpoint Inhibitors$$013296
000008399 6531_ $$aPARP/PI3K
000008399 6531_ $$apolymeric nanoparticles
000008399 6531_ $$acolon cancer
000008399 691__ $$aOHSU/OSU College of Pharmacy$$041367
000008399 7001_ $$aLandry, Madeleine$$uOregon Health and Science University$$041354
000008399 7001_ $$aDuRoss, Allison N.$$uOregon Health and Science University$$041354
000008399 7001_ $$aNeufeld, Megan J.$$uOregon Health and Science University$$041354
000008399 7001_ $$aHahn, Lukas$$uOregon Health and Science University$$041354
000008399 7001_ $$aSahay, Gaurav$$uOregon Health and Science University$$041354
000008399 7001_ $$aLuxenhofer, Robert$$uOregon Health and Science University$$041354
000008399 7001_ $$aSun, Conroy$$uOregon Health and Science University$$041354
000008399 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008399 8564_ $$9dcdff61b-c555-40a0-a77b-81df1a20330a$$s49563$$uhttps://digitalcollections.ohsu.edu/record/8399/files/ResearchWeek.2020.Landry.Madeleine.pdf
000008399 905__ $$a/rest/prod/79/40/7x/96/79407x96w
000008399 980__ $$aResearch Week