@article{IR,
      author = {Athirasala, Avathamsa and Patel, Siddharth and dos Passos  Menezes, Paula and Sahay, Gaurav and Bertassoni, Luiz E.},
      url = {http://digitalcollections.ohsu.edu/record/8400},
      title = {Role of cellular microenvironment in intracellular mRNA  delivery for applications in tissue engineering},
      publisher = {Oregon Health and Science University},
      abstract = {The use of synthetic mRNA-based gene modification offers  several advantages over traditional DNA based gene therapy  including faster translational kinetics, transient  expression and mitigation of risks associated with  insertational mutagenesis and genomic integration.  Accordingly, mRNA technology holds particular promise for  applications in tissue engineering where spatiotemporal  control of gene expression is crucial. Recent advances in  non-viral delivery technologies have significantly  increased the efficiency of intracellular delivery of  synthetic mRNA by modulating mTOR signaling, which has been  identified as a crucial player in mRNA translation.  However, mTOR signaling is regulated by matrix stiffness  through mechanotransductive pathways. Therefore, the  mechanical properties of the engineered tissue must be  tailored for optimal translation and expression of mRNA.},
      number = {IR},
      doi = {https://doi.org/10.6083/jd472x06b},
      recid = {8400},
      address = {2020},
}