TY  - GEN
N2  - Chemical neurotransmission is the major form of communication between neurons and is essential for CNS function. Glutamate is an excitatory fast-acting neurotransmitter that mediates inter-neuronal communication. Evoked and spontaneous release of neurotransmitters are proposed to have distinct roles and rely on divergent vesicle pools and receptors. Moreover, changes in extracellular [Ca2+] ([Ca2+]o) are shown to differentially affect the probability of release for each mechanism. Ca2+ entry via voltage-gated calcium channels (VGCCs) is responsible for evoked release however the same pathway does not contribute to spontaneous release. How does extracellular [Ca2+]o stimulate spontaneous release?
DO  - 10.6083/k930bx55d
DO  - DOI
AB  - Chemical neurotransmission is the major form of communication between neurons and is essential for CNS function. Glutamate is an excitatory fast-acting neurotransmitter that mediates inter-neuronal communication. Evoked and spontaneous release of neurotransmitters are proposed to have distinct roles and rely on divergent vesicle pools and receptors. Moreover, changes in extracellular [Ca2+] ([Ca2+]o) are shown to differentially affect the probability of release for each mechanism. Ca2+ entry via voltage-gated calcium channels (VGCCs) is responsible for evoked release however the same pathway does not contribute to spontaneous release. How does extracellular [Ca2+]o stimulate spontaneous release?
AD  - Portland VA Medical Center
AD  - Portland VA Medical Center
T1  - PLC mediates spontaneous glutamate release triggered by extracellular calcium
DA  - 2020
AU  - Feldthouse, Maya
AU  - Smith, Stephen
L1  - https://digitalcollections.ohsu.edu/record/8410/files/ResearchWeek.2020.Feldthouse.Mary.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8410
L4  - https://digitalcollections.ohsu.edu/record/8410/files/ResearchWeek.2020.Feldthouse.Mary.pdf
KW  - Receptors, Calcium-Sensing
KW  - Calcium
KW  - PLC
KW  - MEPSC
KW  - neurotransmitters
KW  - spontaneous release
TI  - PLC mediates spontaneous glutamate release triggered by extracellular calcium
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8410/files/ResearchWeek.2020.Feldthouse.Mary.pdf
LK  - https://digitalcollections.ohsu.edu/record/8410/files/ResearchWeek.2020.Feldthouse.Mary.pdf
UR  - https://digitalcollections.ohsu.edu/record/8410/files/ResearchWeek.2020.Feldthouse.Mary.pdf
ER  -