000008410 001__ 8410
000008410 005__ 20240415094303.0
000008410 0247_ $$2DOI$$a10.6083/k930bx55d
000008410 037__ $$aIR
000008410 041__ $$aeng
000008410 245__ $$aPLC mediates spontaneous glutamate release triggered by extracellular calcium
000008410 260__ $$bOregon Health and Science University
000008410 269__ $$a2020
000008410 336__ $$aAbstract
000008410 520__ $$aChemical neurotransmission is the major form of communication between neurons and is essential for CNS function. Glutamate is an excitatory fast-acting neurotransmitter that mediates inter-neuronal communication. Evoked and spontaneous release of neurotransmitters are proposed to have distinct roles and rely on divergent vesicle pools and receptors. Moreover, changes in extracellular [Ca2+] ([Ca2+]o) are shown to differentially affect the probability of release for each mechanism. Ca2+ entry via voltage-gated calcium channels (VGCCs) is responsible for evoked release however the same pathway does not contribute to spontaneous release. How does extracellular [Ca2+]o stimulate spontaneous release?
000008410 536__ $$oU.S. Department of Veterans Affairs$$cBX002547
000008410 540__ $$fCC BY
000008410 542__ $$fIn copyright - joint owners
000008410 650__ $$aReceptors, Calcium-Sensing$$035430
000008410 650__ $$aCalcium$$015963
000008410 6531_ $$aPLC
000008410 6531_ $$aMEPSC
000008410 6531_ $$aneurotransmitters
000008410 6531_ $$aspontaneous release
000008410 7001_ $$aFeldthouse, Maya$$uPortland VA Medical Center$$041358
000008410 7001_ $$aSmith, Stephen$$uPortland VA Medical Center$$041358
000008410 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008410 8564_ $$9cc659b94-3afc-45d1-bcf2-b4c516f78f90$$s43442$$uhttps://digitalcollections.ohsu.edu/record/8410/files/ResearchWeek.2020.Feldthouse.Mary.pdf
000008410 905__ $$a/rest/prod/k9/30/bx/55/k930bx55d
000008410 980__ $$aResearch Week