@article{IR,
      author = {King, Dennisha and Dent, Elise and Unni, Vivek},
      url = {http://digitalcollections.ohsu.edu/record/8411},
      title = {Testing whether alpha-synuclein binds specific DNA  conformations},
      publisher = {Oregon Health and Science University},
      abstract = {The abnormal accumulation of the intracellular protein  a-synuclein has been implicated in the pathogenesis of  several neurodegenerative disorders, including Dementia  with Lewy Bodies (DLB), Lewy Body variant Alzheimer's  Disease (LBVAD) & Parkinson's Disease (PD). In these  diseases, known as synucleinopathies, the accumulation of  aggregated a-synuclein in the cytoplasm, known as Lewy  inclusions, is correlated with cellular dysfunction and  death. Although the presence of Lewy inclusions are used as  a marker for a definitive diagnosis of synucleinopathies,  their specific role in neurodegeneration still remains  unclear. The Unni lab has discovered a previously  unrecognized function for the protein a-synuclein in  repairing nuclear DNA damage. Based on this discovery, we  have proposed a new hypothesis that during disease,  a-synuclein protein is sequestered in cytoplasmic Lewy  bodies, decreasing its nuclear DNA damage repair function  and potentially leading to cell death of Lewy  body-containing neurons. We have examined which  confirmations of DNA a-synuclein preferentially binds for  further insight into a-synuclein's normal function in the  nucleus.},
      number = {IR},
      doi = {https://doi.org/10.6083/8336h2513},
      recid = {8411},
      address = {2020},
}