TY  - GEN
N2  - The abnormal accumulation of the intracellular protein a-synuclein has been implicated in the pathogenesis of several neurodegenerative disorders, including Dementia with Lewy Bodies (DLB), Lewy Body variant Alzheimer's Disease (LBVAD) & Parkinson's Disease (PD). In these diseases, known as synucleinopathies, the accumulation of aggregated a-synuclein in the cytoplasm, known as Lewy inclusions, is correlated with cellular dysfunction and death. Although the presence of Lewy inclusions are used as a marker for a definitive diagnosis of synucleinopathies, their specific role in neurodegeneration still remains unclear. The Unni lab has discovered a previously unrecognized function for the protein a-synuclein in repairing nuclear DNA damage. Based on this discovery, we have proposed a new hypothesis that during disease, a-synuclein protein is sequestered in cytoplasmic Lewy bodies, decreasing its nuclear DNA damage repair function and potentially leading to cell death of Lewy body-containing neurons. We have examined which confirmations of DNA a-synuclein preferentially binds for further insight into a-synuclein's normal function in the nucleus.
DO  - 10.6083/8336h2513
DO  - DOI
AB  - The abnormal accumulation of the intracellular protein a-synuclein has been implicated in the pathogenesis of several neurodegenerative disorders, including Dementia with Lewy Bodies (DLB), Lewy Body variant Alzheimer's Disease (LBVAD) & Parkinson's Disease (PD). In these diseases, known as synucleinopathies, the accumulation of aggregated a-synuclein in the cytoplasm, known as Lewy inclusions, is correlated with cellular dysfunction and death. Although the presence of Lewy inclusions are used as a marker for a definitive diagnosis of synucleinopathies, their specific role in neurodegeneration still remains unclear. The Unni lab has discovered a previously unrecognized function for the protein a-synuclein in repairing nuclear DNA damage. Based on this discovery, we have proposed a new hypothesis that during disease, a-synuclein protein is sequestered in cytoplasmic Lewy bodies, decreasing its nuclear DNA damage repair function and potentially leading to cell death of Lewy body-containing neurons. We have examined which confirmations of DNA a-synuclein preferentially binds for further insight into a-synuclein's normal function in the nucleus.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Testing whether alpha-synuclein binds specific DNA conformations
DA  - 2020
AU  - King, Dennisha
AU  - Dent, Elise
AU  - Unni, Vivek
L1  - https://digitalcollections.ohsu.edu/record/8411/files/ResearchWeek.2020.King.Dennisha.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8411
L4  - https://digitalcollections.ohsu.edu/record/8411/files/ResearchWeek.2020.King.Dennisha.pdf
KW  - alpha-Synuclein
KW  - Synucleinopathies
KW  - Neurodegenerative Diseases
KW  - Parkinson Disease
KW  - Lewy Body Disease
KW  - alpha-Synuclein
KW  - DNA Damage
KW  - lewy body dementias
KW  - lewy inclusions
TI  - Testing whether alpha-synuclein binds specific DNA conformations
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8411/files/ResearchWeek.2020.King.Dennisha.pdf
LK  - https://digitalcollections.ohsu.edu/record/8411/files/ResearchWeek.2020.King.Dennisha.pdf
UR  - https://digitalcollections.ohsu.edu/record/8411/files/ResearchWeek.2020.King.Dennisha.pdf
ER  -