@article{IR, author = {Mansoorifar, Amin and Bertassoni, Luiz E.}, url = {http://digitalcollections.ohsu.edu/record/8418}, title = {Bone-on-a-chip - a biomimetic organ-on-a-chip model system to study cancer metastasis}, publisher = {Oregon Health and Science University}, abstract = {Bone tissue is a common site of metastasis, affecting a large number of patients with advanced cancer. The specificity of bone for extravasation of many types of cancers appears to be tightly related to the specific chemo-attractant molecules secreted by bone stromal cells, as well as possible interactions with other non-cancer cells, such as platelets, leukocytes, and monocytes/macrophages. In this study, we combined our rapid bone fabrication method with microfluidic systems to create an organ-on-a-chip system that can mimic the nanoscale mineralization of the native bone tissue and aspects that are relevant to cancer metastasis.}, number = {IR}, doi = {https://doi.org/10.6083/1z40kt45m}, recid = {8418}, address = {2020}, }