TY - GEN AB - Bone tissue is a common site of metastasis, affecting a large number of patients with advanced cancer. The specificity of bone for extravasation of many types of cancers appears to be tightly related to the specific chemo-attractant molecules secreted by bone stromal cells, as well as possible interactions with other non-cancer cells, such as platelets, leukocytes, and monocytes/macrophages. In this study, we combined our rapid bone fabrication method with microfluidic systems to create an organ-on-a-chip system that can mimic the nanoscale mineralization of the native bone tissue and aspects that are relevant to cancer metastasis. AD - Oregon Health and Science University AD - Oregon Health and Science University AU - Mansoorifar, Amin AU - Bertassoni, Luiz E. DA - 2020 DO - 10.6083/1z40kt45m DO - DOI ID - 8418 KW - Microfluidics KW - Bone Neoplasms KW - Microphysiological Systems KW - Neoplasm Metastasis KW - organ-on-a-chip devices KW - bone models KW - bone tissue L1 - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf L2 - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf L4 - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf LA - eng LK - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf N2 - Bone tissue is a common site of metastasis, affecting a large number of patients with advanced cancer. The specificity of bone for extravasation of many types of cancers appears to be tightly related to the specific chemo-attractant molecules secreted by bone stromal cells, as well as possible interactions with other non-cancer cells, such as platelets, leukocytes, and monocytes/macrophages. In this study, we combined our rapid bone fabrication method with microfluidic systems to create an organ-on-a-chip system that can mimic the nanoscale mineralization of the native bone tissue and aspects that are relevant to cancer metastasis. PB - Oregon Health and Science University PY - 2020 T1 - Bone-on-a-chip - a biomimetic organ-on-a-chip model system to study cancer metastasis TI - Bone-on-a-chip - a biomimetic organ-on-a-chip model system to study cancer metastasis UR - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf Y1 - 2020 ER -