TY  - GEN
N2  - Bone tissue is a common site of metastasis, affecting a large number of patients with advanced cancer. The specificity of bone for extravasation of many types of cancers appears to be tightly related to the specific chemo-attractant molecules secreted by bone stromal cells, as well as possible interactions with other non-cancer cells, such as platelets, leukocytes, and monocytes/macrophages. In this study, we combined our rapid bone fabrication method with microfluidic systems to create an organ-on-a-chip system that can mimic the nanoscale mineralization of the native bone tissue and aspects that are relevant to cancer metastasis.
DO  - 10.6083/1z40kt45m
DO  - DOI
AB  - Bone tissue is a common site of metastasis, affecting a large number of patients with advanced cancer. The specificity of bone for extravasation of many types of cancers appears to be tightly related to the specific chemo-attractant molecules secreted by bone stromal cells, as well as possible interactions with other non-cancer cells, such as platelets, leukocytes, and monocytes/macrophages. In this study, we combined our rapid bone fabrication method with microfluidic systems to create an organ-on-a-chip system that can mimic the nanoscale mineralization of the native bone tissue and aspects that are relevant to cancer metastasis.
AD  - Oregon Health and Science University
AD  - Oregon Health and Science University
T1  - Bone-on-a-chip - a biomimetic organ-on-a-chip model system to study cancer metastasis
DA  - 2020
AU  - Mansoorifar, Amin
AU  - Bertassoni, Luiz E.
L1  - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf
PB  - Oregon Health and Science University
LA  - eng
PY  - 2020
ID  - 8418
L4  - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf
KW  - Microfluidics
KW  - Bone Neoplasms
KW  - Microphysiological Systems
KW  - Neoplasm Metastasis
KW  - organ-on-a-chip devices
KW  - bone models
KW  - bone tissue
TI  - Bone-on-a-chip - a biomimetic organ-on-a-chip model system to study cancer metastasis
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf
LK  - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf
UR  - https://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf
ER  -