000008418 001__ 8418
000008418 005__ 20240328083226.0
000008418 0247_ $$2DOI$$a10.6083/1z40kt45m
000008418 037__ $$aIR
000008418 041__ $$aeng
000008418 245__ $$aBone-on-a-chip - a biomimetic organ-on-a-chip model system to study cancer metastasis
000008418 260__ $$bOregon Health and Science University
000008418 269__ $$a2020
000008418 336__ $$aAbstract
000008418 520__ $$aBone tissue is a common site of metastasis, affecting a large number of patients with advanced cancer. The specificity of bone for extravasation of many types of cancers appears to be tightly related to the specific chemo-attractant molecules secreted by bone stromal cells, as well as possible interactions with other non-cancer cells, such as platelets, leukocytes, and monocytes/macrophages. In this study, we combined our rapid bone fabrication method with microfluidic systems to create an organ-on-a-chip system that can mimic the nanoscale mineralization of the native bone tissue and aspects that are relevant to cancer metastasis.
000008418 540__ $$fCC BY
000008418 542__ $$fIn copyright - joint owners
000008418 650__ $$aMicrofluidics$$035383
000008418 650__ $$aBone Neoplasms$$015731
000008418 650__ $$aMicrophysiological Systems$$013975
000008418 650__ $$aNeoplasm Metastasis$$022751
000008418 6531_ $$aorgan-on-a-chip devices
000008418 6531_ $$abone models
000008418 6531_ $$abone tissue
000008418 691__ $$aSchool of Dentistry$$041368
000008418 7001_ $$aMansoorifar, Amin$$uOregon Health and Science University$$041354
000008418 7001_ $$aBertassoni, Luiz E.$$uOregon Health and Science University$$041354
000008418 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008418 8564_ $$937c4bb20-7fa5-4cb3-b7cc-57ba784437eb$$s73572$$uhttps://digitalcollections.ohsu.edu/record/8418/files/ResearchWeek.2020.Mansoorifar.Amin.pdf
000008418 905__ $$a/rest/prod/1z/40/kt/45/1z40kt45m
000008418 980__ $$aResearch Week