TY  - GEN
AB  - Membrane protein folding is a fundamental yet poorly understood process in cell biology, despite membrane proteins comprising a substantial portion of cellular proteomes and playing critical roles in signaling, transport, and metabolism. Misfolding of these proteins underlies numerous diseases, making them important targets for therapeutic intervention. While pharmacological agents capable of correcting membrane protein misfolding have shown promise, their mechanisms of action and the early biogenesis of membrane proteins remain unclear. This dissertation addresses how polytopic membrane proteins are initially integrated into the lipid bilayer and begin folding. Understanding these early folding pathways is essential for elucidating disease mechanisms and for the rational design of therapies targeting misfolded membrane proteins or the cellular machinery that governs their biogenesis.
AD  - Oregon Health and Science University
AU  - Pitonzo, David
DA  - 2007
DO  - 10.6083/M4T43R37
DO  - DOI
ED  - Skach, Bill
ED  - Mentor
ID  - 842
KW  - Cystic Fibrosis Transmembrane Conductance Regulator
KW  - Membrane Proteins
KW  - Aquaporin 4
KW  - signal sequence receptor
L1  - https://digitalcollections.ohsu.edu/record/842/files/845_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/842/files/845_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/842/files/845_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/842/files/845_etd.pdf
N2  - Membrane protein folding is a fundamental yet poorly understood process in cell biology, despite membrane proteins comprising a substantial portion of cellular proteomes and playing critical roles in signaling, transport, and metabolism. Misfolding of these proteins underlies numerous diseases, making them important targets for therapeutic intervention. While pharmacological agents capable of correcting membrane protein misfolding have shown promise, their mechanisms of action and the early biogenesis of membrane proteins remain unclear. This dissertation addresses how polytopic membrane proteins are initially integrated into the lipid bilayer and begin folding. Understanding these early folding pathways is essential for elucidating disease mechanisms and for the rational design of therapies targeting misfolded membrane proteins or the cellular machinery that governs their biogenesis.
PB  - Oregon Health and Science University
PY  - 2007
T1  - Molecular mechanisms of Sec61-mediated polytopic protein membrane integration
TI  - Molecular mechanisms of Sec61-mediated polytopic protein membrane integration
UR  - https://digitalcollections.ohsu.edu/record/842/files/845_etd.pdf
Y1  - 2007
ER  -