000000842 001__ 842
000000842 005__ 20260421161058.0
000000842 0247_ $$2DOI$$a10.6083/M4T43R37
000000842 037__ $$aETD
000000842 245__ $$aMolecular mechanisms of Sec61-mediated polytopic protein membrane integration
000000842 260__ $$bOregon Health and Science University
000000842 269__ $$a2007
000000842 336__ $$aDissertation
000000842 502__ $$bPh.D.
000000842 520__ $$aMembrane protein folding is a fundamental yet poorly understood process in cell biology, despite membrane proteins comprising a substantial portion of cellular proteomes and playing critical roles in signaling, transport, and metabolism. Misfolding of these proteins underlies numerous diseases, making them important targets for therapeutic intervention. While pharmacological agents capable of correcting membrane protein misfolding have shown promise, their mechanisms of action and the early biogenesis of membrane proteins remain unclear. This dissertation addresses how polytopic membrane proteins are initially integrated into the lipid bilayer and begin folding. Understanding these early folding pathways is essential for elucidating disease mechanisms and for the rational design of therapies targeting misfolded membrane proteins or the cellular machinery that governs their biogenesis.
000000842 540__ $$fCC BY
000000842 542__ $$fIn copyright - single owner
000000842 650__ $$aCystic Fibrosis Transmembrane Conductance Regulator$$031275
000000842 650__ $$aMembrane Proteins$$022009
000000842 650__ $$aAquaporin 4$$036851
000000842 6531_ $$asignal sequence receptor
000000842 691__ $$aSchool of Medicine$$041369
000000842 692__ $$aDepartment of Physiology and Pharmacology$$041442
000000842 7001_ $$aPitonzo, David$$uOregon Health and Science University$$041354
000000842 7201_ $$aSkach, Bill$$uOregon Health and Science University$$041354$$7Personal$$eMentor
000000842 8564_ $$940b13378-4bef-4967-8111-6078e3e72e37$$s7248865$$uhttps://digitalcollections.ohsu.edu/record/842/files/845_etd.pdf$$ePublic$$26e4dcf7aa63ecd3bdd66146c52e2c6d0$$31
000000842 901__ $$a&lt;p&gt;These documents are archival records. They are retained for historical reference only. &lt;/p&gt;&lt;p&gt;&lt;b&gt;Need an accessible version? Use the ‘Get Accessible Copy’ link above.&lt;/b&gt;&lt;/p&gt;
000000842 905__ $$a/rest/prod/3x/81/6m/69/3x816m69m
000000842 909CO $$ooai:digitalcollections.ohsu.edu:842$$pstudent-work
000000842 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000842 980__ $$aTheses and Dissertations