000008427 001__ 8427 000008427 005__ 20240410085045.0 000008427 0247_ $$2DOI$$a10.6083/m039k561v 000008427 037__ $$aIR 000008427 041__ $$aeng 000008427 245__ $$aInference of functional redundancy in cancer genes via a co-mutation frequency network 000008427 260__ $$bOregon Health and Science University 000008427 269__ $$a2020 000008427 336__ $$aAbstract 000008427 520__ $$aI have developed a co-mutation frequency network to infer functional redundancy between pairs of cancer genes. This analysis builds on previous work that leverages mutual exclusivity, or low co-mutation frequency, as a way to investigate the genetic mechanisms of tumorigenesis. 000008427 540__ $$fCC BY 000008427 542__ $$fIn copyright - single owner 000008427 650__ $$aNeoplasms$$022758 000008427 650__ $$aGenetics$$019472 000008427 650__ $$aCarcinogenesis$$040251 000008427 6531_ $$acancer 000008427 6531_ $$anetworks 000008427 6531_ $$apathway analysis 000008427 691__ $$aSchool of Medicine$$041369 000008427 692__ $$aDepartment of Medical Informatics and Clinical Epidemiology$$041422 000008427 7001_ $$aKlocke, Christopher$$uOregon Health and Science University$$041354 000008427 711__ $$aResearch Week$$uOregon Health and Science University$$d2020 000008427 8564_ $$94e377d04-8bd4-4114-9780-b10508399c36$$s103396$$uhttps://digitalcollections.ohsu.edu/record/8427/files/ResearchWeek.2020.Klocke.Christopher.pdf 000008427 905__ $$a/rest/prod/m0/39/k5/61/m039k561v 000008427 980__ $$aResearch Week