000008434 001__ 8434
000008434 005__ 20240412154807.0
000008434 0247_ $$2DOI$$a10.6083/bn999752k
000008434 037__ $$aIR
000008434 041__ $$aeng
000008434 245__ $$aNovel protein-protein interactions with c-Myc at the nuclear pore basket
000008434 260__ $$bOregon Health and Science University$$010958
000008434 269__ $$a2020
000008434 336__ $$aAbstract
000008434 520__ $$aIn recent studies, c-Myc has been shown to localize to the nuclear pore complex (NPC) after specific post-translational modifications. The localization of c-Myc to the NPC can mediate aspects of stress response to environmental signals, and separate studies show a role for c-Myc in gene gating at the NPC. The c-MYC interacting protein partners at the NPC are still unknown and could potentially contribute to oncogenic responses governed by c-Myc. We utilized a Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins (RIME) experiment to identify proteins, which interact with C-Myc (N-262 Abcam), TPR, and other nuclear pore proteins (Mab414). The identified protein targets from the RIME experiment were then tested in mouse embryonic fibroblasts, pancreatic cancer, and lymphoma cell lines. Currently, we are examining the role of c-Myc and RIME-identified protein interactions to uncover potential therapeutic targets in PDAC.
000008434 540__ $$fCC BY
000008434 542__ $$fIn copyright - joint owners
000008434 650__ $$aGenes, myc$$029010
000008434 650__ $$aNuclear Pore Complex Proteins$$033527
000008434 6531_ $$ac-Myc
000008434 6531_ $$aPDAC
000008434 6531_ $$aRIME
000008434 6531_ $$aoncology
000008434 691__ $$aSchool of Medicine$$041369
000008434 692__ $$aDepartment of Molecular and Medical Genetics$$041428
000008434 7001_ $$aDewson, Gabrielle$$uOregon Health and Science University$$041354
000008434 7001_ $$aCohn, Gabriel$$uOregon Health and Science University$$041354
000008434 7001_ $$aSu, Yulong$$uOregon Health and Science University$$041354
000008434 711__ $$aResearch Week$$uOregon Health and Science University$$d2020
000008434 8564_ $$942ba2158-01b7-419f-8ce0-e1752a9aaf66$$s112774$$uhttps://digitalcollections.ohsu.edu/record/8434/files/ResearchWeek.2020.Dewson.Gabrielle.pdf
000008434 905__ $$a/rest/prod/bn/99/97/52/bn999752k
000008434 980__ $$aResearch Week