000000846 001__ 846
000000846 005__ 20260423130649.0
000000846 0247_ $$2DOI$$a10.6083/M4959FKR
000000846 037__ $$aETD
000000846 245__ $$aThe risk of Barrett's esophagus in patients with mild gastroesophageal reflux disease symptoms in the context of proton-pump inhibitor use
000000846 260__ $$bOregon Health and Science University
000000846 269__ $$a2007
000000846 336__ $$aThesis
000000846 502__ $$bM.P.H.
000000846 520__ $$aGastroesophageal reflux disease (GERD) is a highly prevalent chronic condition characterized by symptoms or mucosal damage resulting from abnormal reflux of gastric contents into the esophagus. While heartburn and regurgitation are typical manifestations, GERD may also present with extraesophageal symptoms and lead to complications such as erosive esophagitis, strictures, and Barrett’s esophagus. Given its high prevalence, substantial health care costs, and role as a key risk factor for esophageal adenocarcinoma, GERD represents a significant public health concern. Current management emphasizes empirical acid suppression therapy, with diagnostic endoscopy reserved for patients with alarm symptoms or chronic disease at risk for complications such as Barrett’s esophagus. Challenges remain in identifying individuals most likely to benefit from screening and surveillance strategies.
000000846 540__ $$fCC BY
000000846 542__ $$fIn copyright - single owner
000000846 650__ $$aEsophageal Neoplasms$$018636
000000846 650__ $$aProton Pump Inhibitors$$037765
000000846 650__ $$aBarrett Esophagus$$015366
000000846 650__ $$aGastroesophageal Reflux$$019416
000000846 650__ $$aEsophagitis$$018639
000000846 650__ $$aAdenocarcinoma$$014225
000000846 650__ $$aChronic Disease$$016715
000000846 650__ $$aHealth Care Costs$$029646
000000846 650__ $$aHeartburn$$019962
000000846 6531_ $$aphysiopathology
000000846 691__ $$aSchool of Medicine$$041369
000000846 692__ $$aDepartment of Public Health and Preventive Medicine$$041444
000000846 7001_ $$aWichienkuer, Promporn$$uOregon Health and Science University$$041354
000000846 8564_ $$97df61076-befd-4511-a003-645b39fc5877$$s8102313$$uhttps://digitalcollections.ohsu.edu/record/846/files/849_etd.pdf$$ePublic$$26075f0396ad0e9dc7695fd5bdf883463$$31
000000846 901__ $$a<p>These documents are archival records. They are retained for historical reference only. </p><p><b>Need an accessible version? Use the ‘Get Accessible Copy’ link above.</b></p>
000000846 905__ $$a/rest/prod/h4/15/p9/57/h415p9571
000000846 909CO $$ooai:digitalcollections.ohsu.edu:846$$pstudent-work
000000846 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000846 980__ $$aTheses and Dissertations