TY  - GEN
AB  - Acute Myelogenous Leukemia (AML) is an aggressive cancer of the bone marrow that affects both adults and children alike. While many patients achieve remission following induction of chemotherapy, the cancer eventually returns in 40% with increased resistance to cancer drugs. Due to high rates of relapse and drug resistance, the 5-year survival remains less than 25%. Despite mounting evidence  implicating EVs in bone marrow dysfunction, more research is needed to fully map the directional transfer of AML-EVs to recipient cells, and determine how their respective cargos enforce pro-leukemic alterations to the bone marrow and extramedullary tissues. In this thesis, I investigate the fate and function of AML-EV in altering the leukemic microenvironment through direct interactions with HSPCs, supportive stroma and cytotoxic T-lymphocytes.
AU  - Butler, John T.
DA  - 2020
DO  - 10.6083/ht24wk059
DO  - DOI
ID  - 8487
KW  - Bone Marrow
KW  - Extracellular Vesicles
KW  - Exosomes
KW  - acute myeloid leukemia
KW  - immunosuppression
L1  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
L2  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
L4  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
N2  - Acute Myelogenous Leukemia (AML) is an aggressive cancer of the bone marrow that affects both adults and children alike. While many patients achieve remission following induction of chemotherapy, the cancer eventually returns in 40% with increased resistance to cancer drugs. Due to high rates of relapse and drug resistance, the 5-year survival remains less than 25%. Despite mounting evidence  implicating EVs in bone marrow dysfunction, more research is needed to fully map the directional transfer of AML-EVs to recipient cells, and determine how their respective cargos enforce pro-leukemic alterations to the bone marrow and extramedullary tissues. In this thesis, I investigate the fate and function of AML-EV in altering the leukemic microenvironment through direct interactions with HSPCs, supportive stroma and cytotoxic T-lymphocytes.
PB  - Oregon Health and Science University
PY  - 2020
T1  - Extracellular vesicle trafficking enforces microenvironmental dysregulation in Acute Myeloid Leukemia
TI  - Extracellular vesicle trafficking enforces microenvironmental dysregulation in Acute Myeloid Leukemia
UR  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
Y1  - 2020
ER  -