TY  - GEN
N2  - Acute Myelogenous Leukemia (AML) is an aggressive cancer of the bone marrow that affects both adults and children alike. While many patients achieve remission following induction of chemotherapy, the cancer eventually returns in 40% with increased resistance to cancer drugs. Due to high rates of relapse and drug resistance, the 5-year survival remains less than 25%. Despite mounting evidence  implicating EVs in bone marrow dysfunction, more research is needed to fully map the directional transfer of AML-EVs to recipient cells, and determine how their respective cargos enforce pro-leukemic alterations to the bone marrow and extramedullary tissues. In this thesis, I investigate the fate and function of AML-EV in altering the leukemic microenvironment through direct interactions with HSPCs, supportive stroma and cytotoxic T-lymphocytes.
DO  - 10.6083/ht24wk059
DO  - DOI
AB  - Acute Myelogenous Leukemia (AML) is an aggressive cancer of the bone marrow that affects both adults and children alike. While many patients achieve remission following induction of chemotherapy, the cancer eventually returns in 40% with increased resistance to cancer drugs. Due to high rates of relapse and drug resistance, the 5-year survival remains less than 25%. Despite mounting evidence  implicating EVs in bone marrow dysfunction, more research is needed to fully map the directional transfer of AML-EVs to recipient cells, and determine how their respective cargos enforce pro-leukemic alterations to the bone marrow and extramedullary tissues. In this thesis, I investigate the fate and function of AML-EV in altering the leukemic microenvironment through direct interactions with HSPCs, supportive stroma and cytotoxic T-lymphocytes.
T1  - Extracellular vesicle trafficking enforces microenvironmental dysregulation in Acute Myeloid Leukemia
DA  - 2020
AU  - Butler, John T.
L1  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8487
L4  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
KW  - Bone Marrow
KW  - Extracellular Vesicles
KW  - Exosomes
KW  - acute myeloid leukemia
KW  - immunosuppression
TI  - Extracellular vesicle trafficking enforces microenvironmental dysregulation in Acute Myeloid Leukemia
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
UR  - https://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
ER  -