000008487 001__ 8487
000008487 005__ 20240124114302.0
000008487 0247_ $$2DOI$$a10.6083/ht24wk059
000008487 037__ $$aETD
000008487 245__ $$aExtracellular vesicle trafficking enforces microenvironmental dysregulation in Acute Myeloid Leukemia
000008487 260__ $$bOregon Health and Science University
000008487 269__ $$a2020
000008487 336__ $$aDissertation
000008487 502__ $$bPh.D.
000008487 520__ $$aAcute Myelogenous Leukemia (AML) is an aggressive cancer of the bone marrow that affects both adults and children alike. While many patients achieve remission following induction of chemotherapy, the cancer eventually returns in 40% with increased resistance to cancer drugs. Due to high rates of relapse and drug resistance, the 5-year survival remains less than 25%. Despite mounting evidence  implicating EVs in bone marrow dysfunction, more research is needed to fully map the directional transfer of AML-EVs to recipient cells, and determine how their respective cargos enforce pro-leukemic alterations to the bone marrow and extramedullary tissues. In this thesis, I investigate the fate and function of AML-EV in altering the leukemic microenvironment through direct interactions with HSPCs, supportive stroma and cytotoxic T-lymphocytes.
000008487 542__ $$fIn copyright - single owner
000008487 650__ $$aBone Marrow$$015725
000008487 650__ $$aExtracellular Vesicles$$011111
000008487 650__ $$aExosomes$$038258
000008487 6531_ $$aacute myeloid leukemia
000008487 6531_ $$aimmunosuppression
000008487 691__ $$aSchool of Medicine$$041369
000008487 692__ $$aDepartment of Biomedical Engineering$$041397
000008487 7001_ $$aButler, John T.
000008487 8564_ $$9801c8796-2127-4f44-8260-2577c124b634$$s21701714$$uhttps://digitalcollections.ohsu.edu/record/8487/files/Butler.John.2020.pdf
000008487 905__ $$a/rest/prod/ht/24/wk/05/ht24wk059
000008487 909CO $$ooai:digitalcollections.ohsu.edu:8487$$pstudent-work
000008487 980__ $$aTheses and Dissertations