TY  - GEN
AB  - Female reproductive function is tightly linked to metabolic status, requiring sufficient energy for fertility. Negative energy balance—caused by inadequate intake or excessive expenditure—triggers adaptive mechanisms to conserve energy, including suppression of ovarian cycling in adulthood and delayed puberty during development. These responses prevent the high metabolic costs of gestation and lactation and may involve both active inhibition and failure of permissive growth signals. Understanding how metabolic cues regulate reproduction has critical implications for women’s health and could inform therapeutic strategies for infertility associated with energy imbalance.
AD  - Oregon Health and Science University
AU  - True, Cadence
DA  - 2012
DO  - 10.6083/M4HQ3WXQ
DO  - DOI
ED  - Smith, Susan
ED  - Advisor
ED  - Mentor
ID  - 852
KW  - Neuropeptides
KW  - Gonadotropin-Releasing Hormone
KW  - Neurokinin B
KW  - Kisspeptins
KW  - Amenorrhea
KW  - Lactation
KW  - Reproduction
KW  - Puberty, Delayed
KW  - Pregnancy
L1  - https://digitalcollections.ohsu.edu/record/852/files/855_etd.pdf
L2  - https://digitalcollections.ohsu.edu/record/852/files/855_etd.pdf
L4  - https://digitalcollections.ohsu.edu/record/852/files/855_etd.pdf
LK  - https://digitalcollections.ohsu.edu/record/852/files/855_etd.pdf
N2  - Female reproductive function is tightly linked to metabolic status, requiring sufficient energy for fertility. Negative energy balance—caused by inadequate intake or excessive expenditure—triggers adaptive mechanisms to conserve energy, including suppression of ovarian cycling in adulthood and delayed puberty during development. These responses prevent the high metabolic costs of gestation and lactation and may involve both active inhibition and failure of permissive growth signals. Understanding how metabolic cues regulate reproduction has critical implications for women’s health and could inform therapeutic strategies for infertility associated with energy imbalance.
PB  - Oregon Health and Science University
PY  - 2012
T1  - Regulation of arcuate nucleus kisspeptin/neurokinin B and gonadotropin-releasing hormone during negative energy balance
TI  - Regulation of arcuate nucleus kisspeptin/neurokinin B and gonadotropin-releasing hormone during negative energy balance
UR  - https://digitalcollections.ohsu.edu/record/852/files/855_etd.pdf
Y1  - 2012
ER  -