000000852 001__ 852
000000852 005__ 20251229140325.0
000000852 0247_ $$2DOI$$a10.6083/M4HQ3WXQ
000000852 037__ $$aETD
000000852 245__ $$aRegulation of arcuate nucleus kisspeptin/neurokinin B and gonadotropin-releasing hormone during negative energy balance
000000852 260__ $$bOregon Health and Science University
000000852 269__ $$a2012
000000852 336__ $$aDissertation
000000852 502__ $$bPh.D.
000000852 502__ $$gNeuroscience
000000852 520__ $$aFemale reproductive function is tightly linked to metabolic status, requiring sufficient energy for fertility. Negative energy balance—caused by inadequate intake or excessive expenditure—triggers adaptive mechanisms to conserve energy, including suppression of ovarian cycling in adulthood and delayed puberty during development. These responses prevent the high metabolic costs of gestation and lactation and may involve both active inhibition and failure of permissive growth signals. Understanding how metabolic cues regulate reproduction has critical implications for women’s health and could inform therapeutic strategies for infertility associated with energy imbalance.
000000852 540__ $$fCC BY
000000852 542__ $$fIn copyright - single owner
000000852 650__ $$aNeuropeptides$$022863
000000852 650__ $$aGonadotropin-Releasing Hormone$$021474
000000852 650__ $$aNeurokinin B$$028292
000000852 650__ $$aKisspeptins$$039618
000000852 650__ $$aAmenorrhea$$014537
000000852 650__ $$aLactation$$021283
000000852 650__ $$aReproduction$$025329
000000852 650__ $$aPuberty, Delayed$$024879
000000852 650__ $$aPregnancy$$024523
000000852 691__ $$aSchool of Medicine$$041369
000000852 692__ $$aVollum Institute$$041509
000000852 7001_ $$aTrue, Cadence$$uOregon Health and Science University$$041354
000000852 7201_ $$aSmith, Susan$$uOregon Health and Science University$$041354$$7Personal$$eAdvisor$$eMentor
000000852 8564_ $$992f0bb1e-3e8e-47c8-9039-a46a01d1d239$$s5097045$$uhttps://digitalcollections.ohsu.edu/record/852/files/855_etd.pdf$$ePublic$$28237cfa03fc8735faa77295ee61a51d1$$31
000000852 905__ $$a/rest/prod/p5/54/7r/41/p5547r413
000000852 909CO $$ooai:digitalcollections.ohsu.edu:852$$pstudent-work
000000852 980__ $$aTheses and Dissertations