TY  - GEN
AB  - There is an urgent unmet need for short-term interventions to prevent infection in infants exposed to HIV-1 at birth, who have higher mortality rates than infants infected at an older age. Although passively administered antibodies disperse into tissues more slowly than antiretroviral drugs (ART), potent broadly neutralizing monoclonal antibodies (bNAbs) are an attractive approach for post-exposure prophylaxis because of their longer half-life, good safety profile, and the potential for opsonization and Fc-mediated killing of infected cells.
AU  - Shapiro, Mariya B.
DA  - 2020
DO  - 10.6083/st74cr11p
DO  - DOI
ID  - 8556
KW  - Broadly Neutralizing Antibodies
KW  - HIV-1
KW  - Post-Exposure Prophylaxis
KW  - Macaca mulatta
KW  - monoclonal antibodies
KW  - newborn infant
L1  - https://digitalcollections.ohsu.edu/record/8556/files/Shapiro.Mariya.2020.pdf
L2  - https://digitalcollections.ohsu.edu/record/8556/files/Shapiro.Mariya.2020.pdf
L4  - https://digitalcollections.ohsu.edu/record/8556/files/Shapiro.Mariya.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8556/files/Shapiro.Mariya.2020.pdf
N2  - There is an urgent unmet need for short-term interventions to prevent infection in infants exposed to HIV-1 at birth, who have higher mortality rates than infants infected at an older age. Although passively administered antibodies disperse into tissues more slowly than antiretroviral drugs (ART), potent broadly neutralizing monoclonal antibodies (bNAbs) are an attractive approach for post-exposure prophylaxis because of their longer half-life, good safety profile, and the potential for opsonization and Fc-mediated killing of infected cells.
PB  - Oregon Health and Science University
PY  - 2020
T1  - Broadly neutralizing antibody therapy as post-exposure prophylaxis in a nonhuman primate model  of perinatal HIV infection
TI  - Broadly neutralizing antibody therapy as post-exposure prophylaxis in a nonhuman primate model  of perinatal HIV infection
UR  - https://digitalcollections.ohsu.edu/record/8556/files/Shapiro.Mariya.2020.pdf
Y1  - 2020
ER  -