000008556 001__ 8556
000008556 005__ 20240124114303.0
000008556 0247_ $$2DOI$$a10.6083/st74cr11p
000008556 037__ $$aETD
000008556 245__ $$aBroadly neutralizing antibody therapy as post-exposure prophylaxis in a nonhuman primate model  of perinatal HIV infection
000008556 260__ $$bOregon Health and Science University
000008556 269__ $$a2020
000008556 336__ $$aDissertation
000008556 502__ $$bPh.D.
000008556 520__ $$aThere is an urgent unmet need for short-term interventions to prevent infection in infants exposed to HIV-1 at birth, who have higher mortality rates than infants infected at an older age. Although passively administered antibodies disperse into tissues more slowly than antiretroviral drugs (ART), potent broadly neutralizing monoclonal antibodies (bNAbs) are an attractive approach for post-exposure prophylaxis because of their longer half-life, good safety profile, and the potential for opsonization and Fc-mediated killing of infected cells.
000008556 542__ $$fIn copyright - single owner
000008556 650__ $$aBroadly Neutralizing Antibodies$$013185
000008556 650__ $$aHIV-1$$028454
000008556 650__ $$aPost-Exposure Prophylaxis$$038798
000008556 650__ $$aMacaca mulatta$$021724
000008556 6531_ $$amonoclonal antibodies
000008556 6531_ $$anewborn infant
000008556 691__ $$aSchool of Medicine$$041369
000008556 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000008556 7001_ $$aShapiro, Mariya B.
000008556 8564_ $$9ef626674-f344-4bef-aa41-cb6d13241e37$$s6900587$$uhttps://digitalcollections.ohsu.edu/record/8556/files/Shapiro.Mariya.2020.pdf
000008556 905__ $$a/rest/prod/st/74/cr/11/st74cr11p
000008556 909CO $$ooai:digitalcollections.ohsu.edu:8556$$pstudent-work
000008556 980__ $$aTheses and Dissertations