@article{ETD,
      school = {Ph.D.},
      author = {Torres, Eileen R.S.},
      url = {http://digitalcollections.ohsu.edu/record/8572},
      title = {Role of Apolipoprotein E Isoform in stress-related changes  in behavior and cognition},
      publisher = {Oregon Health and Science University},
      abstract = {Stress is a necessary physiological response to external  pressures on homeostasis. However, extreme or chronic  exposure, i.e. trauma, can lead to debilitating disorders  such as Post-Traumatic Stress Disorder (PTSD). Symptoms of  PTSD include nightmares of the trauma, general cognitive  dysfunction, changes in arousal, and avoidance behavior.  Previous research has demonstrated that 30-70% of the  variation in PTSD can be explained by heritability. Recent  work shows that the genetic factor, apolipoprotein E (apoE)  may differentially influence PTSD susceptibility and  symptom severity. ApoE helps regulate lipid transport and  metabolism throughout the body, including the brain. It  exists in humans as three isoforms: E2, E3, and E4. Both  mouse models and human studies have shown that carrying the  E2 allele corresponds to greater PTSD-related symptoms and  in humans, greater susceptibility after trauma. However,  other studies have found conflicting evidence and suggest  the association between apoE isoform and PTSD is still  unclear.},
      number = {ETD},
      doi = {https://doi.org/10.6083/kk91fm098},
      recid = {8572},
      address = {2020},
}