TY  - GEN
AB  - Stress is a necessary physiological response to external pressures on homeostasis. However, extreme or chronic exposure, i.e. trauma, can lead to debilitating disorders such as Post-Traumatic Stress Disorder (PTSD). Symptoms of PTSD include nightmares of the trauma, general cognitive dysfunction, changes in arousal, and avoidance behavior. Previous research has demonstrated that 30-70% of the variation in PTSD can be explained by heritability. Recent work shows that the genetic factor, apolipoprotein E (apoE) may differentially influence PTSD susceptibility and symptom severity. ApoE helps regulate lipid transport and metabolism throughout the body, including the brain. It exists in humans as three isoforms: E2, E3, and E4. Both mouse models and human studies have shown that carrying the E2 allele corresponds to greater PTSD-related symptoms and in humans, greater susceptibility after trauma. However, other studies have found conflicting evidence and suggest the association between apoE isoform and PTSD is still unclear.
AU  - Torres, Eileen R.S.
DA  - 2020
DO  - 10.6083/kk91fm098
DO  - DOI
ID  - 8572
KW  - Behavior
KW  - Apolipoproteins E
KW  - Mice
KW  - psychological stress
KW  - posttraumatic stress disorder
KW  - 7-ketocholesterol
KW  - ptsd
L1  - https://digitalcollections.ohsu.edu/record/8572/files/Torres.Eileen.2020.pdf
L2  - https://digitalcollections.ohsu.edu/record/8572/files/Torres.Eileen.2020.pdf
L4  - https://digitalcollections.ohsu.edu/record/8572/files/Torres.Eileen.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8572/files/Torres.Eileen.2020.pdf
N2  - Stress is a necessary physiological response to external pressures on homeostasis. However, extreme or chronic exposure, i.e. trauma, can lead to debilitating disorders such as Post-Traumatic Stress Disorder (PTSD). Symptoms of PTSD include nightmares of the trauma, general cognitive dysfunction, changes in arousal, and avoidance behavior. Previous research has demonstrated that 30-70% of the variation in PTSD can be explained by heritability. Recent work shows that the genetic factor, apolipoprotein E (apoE) may differentially influence PTSD susceptibility and symptom severity. ApoE helps regulate lipid transport and metabolism throughout the body, including the brain. It exists in humans as three isoforms: E2, E3, and E4. Both mouse models and human studies have shown that carrying the E2 allele corresponds to greater PTSD-related symptoms and in humans, greater susceptibility after trauma. However, other studies have found conflicting evidence and suggest the association between apoE isoform and PTSD is still unclear.
PB  - Oregon Health and Science University
PY  - 2020
T1  - Role of Apolipoprotein E Isoform in stress-related changes in behavior and cognition
TI  - Role of Apolipoprotein E Isoform in stress-related changes in behavior and cognition
UR  - https://digitalcollections.ohsu.edu/record/8572/files/Torres.Eileen.2020.pdf
Y1  - 2020
ER  -