@article{ETD,
      recid = {8594},
      author = {Leff, Emily R.},
      title = {Chronic morphine treatment induces heterologous  alterations in acute kinase-dependent desensitization},
      publisher = {Oregon Health and Science University},
      school = {Ph.D.},
      address = {2020},
      number = {ETD},
      abstract = {Opioids such as morphine are still the most effective  analgesics for many types of pain. However, clinical  utility of opioids is limited because long-term use leads  to analgesic tolerance, such that higher concentrations of  opioids are needed to achieve the same analgesic effect.  This is problematic since tolerance to the life-threatening  respiratory depressive effects of opioids develops slower  than to the analgesic effects of opioids. Thus, opioid  tolerance increases risk for overdose and death.},
      url = {http://digitalcollections.ohsu.edu/record/8594},
      doi = {https://doi.org/10.6083/3197xm82x},
}