TY  - GEN
AB  - Opioids such as morphine are still the most effective analgesics for many types of pain. However, clinical utility of opioids is limited because long-term use leads to analgesic tolerance, such that higher concentrations of opioids are needed to achieve the same analgesic effect. This is problematic since tolerance to the life-threatening respiratory depressive effects of opioids develops slower than to the analgesic effects of opioids. Thus, opioid tolerance increases risk for overdose and death.
AU  - Leff, Emily R.
DA  - 2020
DO  - 10.6083/3197xm82x
DO  - DOI
ID  - 8594
KW  - Drug Tolerance
KW  - Phosphorylation
KW  - somatostatin receptors
KW  - mu opioid receptors
KW  - opioids
L1  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
L2  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
L4  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
N2  - Opioids such as morphine are still the most effective analgesics for many types of pain. However, clinical utility of opioids is limited because long-term use leads to analgesic tolerance, such that higher concentrations of opioids are needed to achieve the same analgesic effect. This is problematic since tolerance to the life-threatening respiratory depressive effects of opioids develops slower than to the analgesic effects of opioids. Thus, opioid tolerance increases risk for overdose and death.
PB  - Oregon Health and Science University
PY  - 2020
T1  - Chronic morphine treatment induces heterologous alterations in acute kinase-dependent desensitization
TI  - Chronic morphine treatment induces heterologous alterations in acute kinase-dependent desensitization
UR  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
Y1  - 2020
ER  -