TY  - GEN
N2  - Opioids such as morphine are still the most effective analgesics for many types of pain. However, clinical utility of opioids is limited because long-term use leads to analgesic tolerance, such that higher concentrations of opioids are needed to achieve the same analgesic effect. This is problematic since tolerance to the life-threatening respiratory depressive effects of opioids develops slower than to the analgesic effects of opioids. Thus, opioid tolerance increases risk for overdose and death.
DO  - 10.6083/3197xm82x
DO  - DOI
AB  - Opioids such as morphine are still the most effective analgesics for many types of pain. However, clinical utility of opioids is limited because long-term use leads to analgesic tolerance, such that higher concentrations of opioids are needed to achieve the same analgesic effect. This is problematic since tolerance to the life-threatening respiratory depressive effects of opioids develops slower than to the analgesic effects of opioids. Thus, opioid tolerance increases risk for overdose and death.
T1  - Chronic morphine treatment induces heterologous alterations in acute kinase-dependent desensitization
DA  - 2020
AU  - Leff, Emily R.
L1  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8594
L4  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
KW  - Drug Tolerance
KW  - Phosphorylation
KW  - somatostatin receptors
KW  - mu opioid receptors
KW  - opioids
TI  - Chronic morphine treatment induces heterologous alterations in acute kinase-dependent desensitization
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
UR  - https://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
ER  -