000008594 001__ 8594
000008594 005__ 20240124114304.0
000008594 0247_ $$2DOI$$a10.6083/3197xm82x
000008594 037__ $$aETD
000008594 245__ $$aChronic morphine treatment induces heterologous alterations in acute kinase-dependent desensitization
000008594 260__ $$bOregon Health and Science University
000008594 269__ $$a2020
000008594 336__ $$aDissertation
000008594 502__ $$bPh.D.
000008594 520__ $$aOpioids such as morphine are still the most effective analgesics for many types of pain. However, clinical utility of opioids is limited because long-term use leads to analgesic tolerance, such that higher concentrations of opioids are needed to achieve the same analgesic effect. This is problematic since tolerance to the life-threatening respiratory depressive effects of opioids develops slower than to the analgesic effects of opioids. Thus, opioid tolerance increases risk for overdose and death.
000008594 542__ $$fIn copyright - single owner
000008594 650__ $$aDrug Tolerance$$018089
000008594 650__ $$aPhosphorylation$$024067
000008594 6531_ $$asomatostatin receptors
000008594 6531_ $$amu opioid receptors
000008594 6531_ $$aopioids
000008594 691__ $$aSchool of Medicine$$041369
000008594 692__ $$aVollum Institute$$041509
000008594 7001_ $$aLeff, Emily R.
000008594 8564_ $$9c376f226-392e-402f-9d15-9b1f62bc105a$$s11140821$$uhttps://digitalcollections.ohsu.edu/record/8594/files/Leff.Emily.2020.pdf
000008594 905__ $$a/rest/prod/31/97/xm/82/3197xm82x
000008594 909CO $$ooai:digitalcollections.ohsu.edu:8594$$pstudent-work
000008594 980__ $$aTheses and Dissertations