TY  - THES
N2  - Tissue-resident memory (TRM) CD8+ T cells permanently reside within non-lymphoid tissues where they provide a first-line of defense against invading pathogens. How-ever, the mechanisms regulating their development and the long-term functional consequences following their activation in situ are poorly defined. Here, I use a model of epicutaneous Vaccinia virus infection to investigate two main research questions regarding the development and function of TRM CD8+ T cells. I begin by describing the role that antigen recognition within the skin microenvironment plays in the development of TRM CD8+ T cells. Next, I determine how repeated antigen encounters by mature TRM CD8+ T cells impacts the composition and function of the TRM population.
DO  - 10.6083/5x21tg13g
DO  - DOI
AB  - Tissue-resident memory (TRM) CD8+ T cells permanently reside within non-lymphoid tissues where they provide a first-line of defense against invading pathogens. How-ever, the mechanisms regulating their development and the long-term functional consequences following their activation in situ are poorly defined. Here, I use a model of epicutaneous Vaccinia virus infection to investigate two main research questions regarding the development and function of TRM CD8+ T cells. I begin by describing the role that antigen recognition within the skin microenvironment plays in the development of TRM CD8+ T cells. Next, I determine how repeated antigen encounters by mature TRM CD8+ T cells impacts the composition and function of the TRM population.
T1  - Development and function of tissue-resident memory CD8+ T cells
DA  - 2020
AU  - Hobbs, Samuel J.
L1  - https://digitalcollections.ohsu.edu/record/8596/files/Hobbs.Samuel.2020.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8596
L4  - https://digitalcollections.ohsu.edu/record/8596/files/Hobbs.Samuel.2020.pdf
KW  - Vaccinia virus
KW  - immunology
TI  - Development and function of tissue-resident memory CD8+ T cells
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8596/files/Hobbs.Samuel.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8596/files/Hobbs.Samuel.2020.pdf
UR  - https://digitalcollections.ohsu.edu/record/8596/files/Hobbs.Samuel.2020.pdf
ER  -