000008596 001__ 8596
000008596 005__ 20240124114304.0
000008596 0247_ $$2DOI$$a10.6083/5x21tg13g
000008596 037__ $$aETD
000008596 245__ $$aDevelopment and function of tissue-resident memory CD8+ T cells
000008596 260__ $$bOregon Health and Science University
000008596 269__ $$a2020
000008596 336__ $$aThesis
000008596 502__ $$bPh.D.
000008596 520__ $$aTissue-resident memory (TRM) CD8+ T cells permanently reside within non-lymphoid tissues where they provide a first-line of defense against invading pathogens. How-ever, the mechanisms regulating their development and the long-term functional consequences following their activation in situ are poorly defined. Here, I use a model of epicutaneous Vaccinia virus infection to investigate two main research questions regarding the development and function of TRM CD8+ T cells. I begin by describing the role that antigen recognition within the skin microenvironment plays in the development of TRM CD8+ T cells. Next, I determine how repeated antigen encounters by mature TRM CD8+ T cells impacts the composition and function of the TRM population.
000008596 650__ $$aVaccinia virus$$027696
000008596 6531_ $$aimmunology
000008596 691__ $$aSchool of Medicine$$041369
000008596 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000008596 7001_ $$aHobbs, Samuel J.
000008596 8564_ $$98c8c0c37-ef05-4b46-986b-b72f6de9103a$$s14808157$$uhttps://digitalcollections.ohsu.edu/record/8596/files/Hobbs.Samuel.2020.pdf
000008596 905__ $$a/rest/prod/5x/21/tg/13/5x21tg13g
000008596 909CO $$ooai:digitalcollections.ohsu.edu:8596$$pstudent-work
000008596 980__ $$aTheses and Dissertations