000008643 001__ 8643 000008643 005__ 20240124114305.0 000008643 0247_ $$2DOI$$a10.6083/4x51hj66n 000008643 037__ $$aETD 000008643 245__ $$aExploring the transcriptional and translational profiles of cells across the oligodendrocyte lineage 000008643 260__ $$bOregon Health and Science University 000008643 269__ $$a2020 000008643 336__ $$aThesis 000008643 502__ $$bPh.D. 000008643 520__ $$aOligodendrocytes are specialized central nervous glia that progress through distinct cellular stages, each with its own specific morphological features, specific proteins, and function. Oligodendrocyte progenitor cells (OPCs) represent the proliferative stem cell population that acts to maintain homeostatic oligodendrocyte numbers and have been shown to respond to neural activity as well as injury and disease. The role that oligodendrocytes play in signal propagation by wrapping axons in a non-conducting sheath represents the most well-known function of myelinating oligodendrocytes. 000008643 650__ $$aMyelin Sheath$$022587 000008643 650__ $$aTranscriptome$$039582 000008643 6531_ $$aadaptive myelination 000008643 6531_ $$aoligodenrocyte 000008643 6531_ $$aglial cells 000008643 6531_ $$amyelination 000008643 691__ $$aSchool of Medicine$$041369 000008643 692__ $$aVollum Institute$$041509 000008643 7001_ $$aFoster, Antoinette 000008643 8564_ $$96a94b7ce-f9ca-436f-baf1-db7861cc3db6$$s31843519$$uhttps://digitalcollections.ohsu.edu/record/8643/files/Foster.Antoinette.2020.pdf 000008643 905__ $$a/rest/prod/4x/51/hj/66/4x51hj66n 000008643 909CO $$ooai:digitalcollections.ohsu.edu:8643$$pstudent-work 000008643 980__ $$aTheses and Dissertations