TY  - GEN
N2  - To progress through their normal developmental cycle, Leishmania and related kinetoplastid parasites must sense and respond to extreme fluctuations in the host environment. Gene expression in kinetoplastids is divergent from other eukaryotes in that transcription is not controlled on an individual gene basis. Consequently, post-transcriptional control points such as mRNA stability and translation have been elevated as key determinants of regulation. As with higher eukaryotes, these processes are governed primarily by the interactions of cis-acting elements in mRNA and trans-acting RNA-binding proteins (RBPs). Considerable effort has therefore been devoted to the study of such elements in kinetoplastids; however, few have been implicated in the context of specific stress-response pathways.
DO  - 10.6083/br86b405f
DO  - DOI
AB  - To progress through their normal developmental cycle, Leishmania and related kinetoplastid parasites must sense and respond to extreme fluctuations in the host environment. Gene expression in kinetoplastids is divergent from other eukaryotes in that transcription is not controlled on an individual gene basis. Consequently, post-transcriptional control points such as mRNA stability and translation have been elevated as key determinants of regulation. As with higher eukaryotes, these processes are governed primarily by the interactions of cis-acting elements in mRNA and trans-acting RNA-binding proteins (RBPs). Considerable effort has therefore been devoted to the study of such elements in kinetoplastids; however, few have been implicated in the context of specific stress-response pathways.
T1  - Dissecting mechanisms of purine-responsive gene expression through the lens of the Leishmania donovani purine transporters
DA  - 2020
AU  - Licon, M. Haley
L1  - https://digitalcollections.ohsu.edu/record/8667/files/Licon.Haley.2020.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8667
L4  - https://digitalcollections.ohsu.edu/record/8667/files/Licon.Haley.2020.pdf
KW  - Parasitology
KW  - Purines
KW  - Leishmania
KW  - Gene Expression Regulation
TI  - Dissecting mechanisms of purine-responsive gene expression through the lens of the Leishmania donovani purine transporters
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8667/files/Licon.Haley.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8667/files/Licon.Haley.2020.pdf
UR  - https://digitalcollections.ohsu.edu/record/8667/files/Licon.Haley.2020.pdf
ER  -