000008667 001__ 8667
000008667 005__ 20231129124943.0
000008667 0247_ $$2DOI$$a10.6083/br86b405f
000008667 037__ $$aETD
000008667 245__ $$aDissecting mechanisms of purine-responsive gene expression through the lens of the Leishmania donovani purine transporters
000008667 260__ $$bOregon Health and Science University
000008667 269__ $$a2020
000008667 336__ $$aDissertation
000008667 502__ $$bPh.D.
000008667 520__ $$aTo progress through their normal developmental cycle, Leishmania and related kinetoplastid parasites must sense and respond to extreme fluctuations in the host environment. Gene expression in kinetoplastids is divergent from other eukaryotes in that transcription is not controlled on an individual gene basis. Consequently, post-transcriptional control points such as mRNA stability and translation have been elevated as key determinants of regulation. As with higher eukaryotes, these processes are governed primarily by the interactions of cis-acting elements in mRNA and trans-acting RNA-binding proteins (RBPs). Considerable effort has therefore been devoted to the study of such elements in kinetoplastids; however, few have been implicated in the context of specific stress-response pathways.
000008667 542__ $$fIn copyright - single owner
000008667 650__ $$aParasitology$$023592
000008667 650__ $$aPurines$$024936
000008667 650__ $$aLeishmania$$021389
000008667 650__ $$aGene Expression Regulation$$019437
000008667 691__ $$aSchool of Medicine$$041369
000008667 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000008667 7001_ $$aLicon, M. Haley
000008667 8564_ $$92229c2e9-f100-4936-b153-4dab01b24e0f$$s7386338$$uhttps://digitalcollections.ohsu.edu/record/8667/files/Licon.Haley.2020.pdf
000008667 905__ $$a/rest/prod/br/86/b4/05/br86b405f
000008667 909CO $$ooai:digitalcollections.ohsu.edu:8667$$pstudent-work
000008667 980__ $$aTheses and Dissertations