000000870 001__ 870
000000870 005__ 20260120144839.0
000000870 0247_ $$2DOI$$a10.6083/M46971KG
000000870 037__ $$aETD
000000870 245__ $$aNew insights into the complex regulation and function of ASPP2 tumor suppressor: the discovery of the ΔN-ASPP2 isoform
000000870 260__ $$bOregon Health and Science University
000000870 269__ $$a2013
000000870 336__ $$aDissertation
000000870 502__ $$bPh.D.
000000870 520__ $$aCancer remains the second leading cause of death in the United States, despite recent declines in mortality. Tumor progression involves evading cellular checkpoints, including apoptosis, a key defense against malignancy. Resistance to apoptosis often occurs through disruption of tumor suppressor pathways, notably p53. As a critical transcription factor, p53 mediates responses to genetic damage and oncogenic stress by inducing cell cycle arrest, DNA repair, and apoptosis. Understanding how p53-driven apoptotic signaling is regulated—and how it becomes impaired during tumor evolution—is essential for developing therapies aimed at restoring apoptotic sensitivity, a major goal in cancer treatment.
000000870 540__ $$fCC BY
000000870 542__ $$fIn copyright - single owner
000000870 650__ $$aOncogenes$$023203
000000870 650__ $$aApoptosis$$029778
000000870 650__ $$aProtein Isoforms$$032074
000000870 650__ $$aTumor Suppressor Protein p53$$028922
000000870 650__ $$aApoptosis Regulatory Proteins$$036672
000000870 650__ $$aMembrane Proteins$$022009
000000870 650__ $$aProto-Oncogene Proteins c-myc$$029021
000000870 650__ $$aNeoplastic Processes$$022774
000000870 650__ $$aNeoplasms$$022758
000000870 691__ $$aSchool of Medicine$$041369
000000870 692__ $$aDepartment of Cell, Developmental and Cancer Biology$$041399
000000870 7001_ $$aVan Hook, Kathryn$$uOregon Health and Science University$$041354
000000870 8564_ $$92cd98751-40b3-4365-9a9d-eb304a703578$$s2592298$$uhttps://digitalcollections.ohsu.edu/record/870/files/873_etd.pdf$$ePublic$$25ef6e05fbf7f81903b3cc1cd030c00c1$$31
000000870 905__ $$a/rest/prod/gm/80/hv/40/gm80hv408
000000870 909CO $$ooai:digitalcollections.ohsu.edu:870$$pstudent-work
000000870 956__ $$aGet Accessible Copy$$uhttps://ohsu.libwizard.com/f/requestaccessibledocument
000000870 980__ $$aTheses and Dissertations