TY  - GEN
N2  - Cytomegaloviruses (CMV) are β-herpesviruses that establish persistent, latent infection in their hosts. Human CMV (HCMV) infection causes significant morbidity and mortality in immunosuppressed patients, including transplant recipients. Additionally, HCMV infection exacerbates the development of transplant vascular sclerosis (TVS) and accelerates chronic rejection (CR) of solid organ transplants. Current therapies to control HCMV do not sufficiently prevent this exacerbation of disease, warranting further research. Here, we examine interactions between the host-immune response and CMV-encoded proteins during pathogenesis and viral dissemination, using a rat CMV (RCMV) infection model of rat cardiac transplantation.
DO  - 10.6083/th83m005k
DO  - DOI
AB  - Cytomegaloviruses (CMV) are β-herpesviruses that establish persistent, latent infection in their hosts. Human CMV (HCMV) infection causes significant morbidity and mortality in immunosuppressed patients, including transplant recipients. Additionally, HCMV infection exacerbates the development of transplant vascular sclerosis (TVS) and accelerates chronic rejection (CR) of solid organ transplants. Current therapies to control HCMV do not sufficiently prevent this exacerbation of disease, warranting further research. Here, we examine interactions between the host-immune response and CMV-encoded proteins during pathogenesis and viral dissemination, using a rat CMV (RCMV) infection model of rat cardiac transplantation.
T1  - The role of cytomegalovirus in organ transplant rejection
DA  - 2020
AU  - Jones, Iris K.A.
L1  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020._Supple_Table_17.xlsx
L1  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020.pdf
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8737
L4  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020._Supple_Table_17.xlsx
L4  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020.pdf
KW  - Graft Rejection
KW  - Monocytes
KW  - Cytomegalovirus
KW  - Viral Proteins
KW  - Chemokines
KW  - animal disease models
TI  - The role of cytomegalovirus in organ transplant rejection
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020._Supple_Table_17.xlsx
L2  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020._Supple_Table_17.xlsx
LK  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020.pdf
UR  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020._Supple_Table_17.xlsx
UR  - https://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020.pdf
ER  -