000008737 001__ 8737
000008737 005__ 20240124114308.0
000008737 0247_ $$2DOI$$a10.6083/th83m005k
000008737 037__ $$aETD
000008737 245__ $$aThe role of cytomegalovirus in organ transplant rejection
000008737 260__ $$bOregon Health and Science University
000008737 269__ $$a2020
000008737 336__ $$aDissertation
000008737 502__ $$bPh.D.
000008737 520__ $$aCytomegaloviruses (CMV) are β-herpesviruses that establish persistent, latent infection in their hosts. Human CMV (HCMV) infection causes significant morbidity and mortality in immunosuppressed patients, including transplant recipients. Additionally, HCMV infection exacerbates the development of transplant vascular sclerosis (TVS) and accelerates chronic rejection (CR) of solid organ transplants. Current therapies to control HCMV do not sufficiently prevent this exacerbation of disease, warranting further research. Here, we examine interactions between the host-immune response and CMV-encoded proteins during pathogenesis and viral dissemination, using a rat CMV (RCMV) infection model of rat cardiac transplantation.
000008737 542__ $$fIn copyright - single owner
000008737 650__ $$aGraft Rejection$$019715
000008737 650__ $$aMonocytes$$022414
000008737 650__ $$aCytomegalovirus$$017352
000008737 650__ $$aViral Proteins$$027836
000008737 650__ $$aChemokines$$031204
000008737 6531_ $$aanimal disease models
000008737 691__ $$aSchool of Medicine$$041369
000008737 692__ $$aDepartment of Molecular Microbiology and Immunology$$041429
000008737 7001_ $$aJones, Iris K.A.
000008737 8564_ $$9c9668e7e-c93d-4796-bf11-5541cf6a897d$$s3322271$$uhttps://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020._Supple_Table_17.xlsx
000008737 8564_ $$9bf841d83-91b3-4fe9-ad83-664ea070a156$$s4490380$$uhttps://digitalcollections.ohsu.edu/record/8737/files/Jones.Iris.2020.pdf
000008737 905__ $$a/rest/prod/th/83/m0/05/th83m005k
000008737 909CO $$ooai:digitalcollections.ohsu.edu:8737$$pstudent-work
000008737 980__ $$aTheses and Dissertations