TY  - GEN
N2  - Contributing to proteomic diversity, alternative splicing of pre-mRNA is widespread in the human transcriptome and can greatly influence regulation of both normal and disease-related cellular phenotypes. Similar to gene expression, alternative splicing does not occur independently, but in a coordinated fashion throughout the transcriptome in order to maintain proper cellular function. Gene co-expression networks have been widely used as an approach to elucidate coordinated regulatory patterns of gene transcription. Studies have shown that genome-wide expression can occur in the form of network modules consisting of highly co-expressed genes operating within specific cellular pathways. Such modules are often well-preserved across similar biological systems and associated with various phenotypes. Here we demonstrate a framework for de novo network inference of co-splicing in the form of modules consisting of complex alternative splicing variants.
DO  - 10.6083/5h73pw81c
DO  - DOI
AB  - Contributing to proteomic diversity, alternative splicing of pre-mRNA is widespread in the human transcriptome and can greatly influence regulation of both normal and disease-related cellular phenotypes. Similar to gene expression, alternative splicing does not occur independently, but in a coordinated fashion throughout the transcriptome in order to maintain proper cellular function. Gene co-expression networks have been widely used as an approach to elucidate coordinated regulatory patterns of gene transcription. Studies have shown that genome-wide expression can occur in the form of network modules consisting of highly co-expressed genes operating within specific cellular pathways. Such modules are often well-preserved across similar biological systems and associated with various phenotypes. Here we demonstrate a framework for de novo network inference of co-splicing in the form of modules consisting of complex alternative splicing variants.
AD  - Oregon Health and Science University
T1  - Network-based alternative splicing signatures of drug response in AML
DA  - 2020
AU  - Egger, Julian
L1  - https://digitalcollections.ohsu.edu/record/8743/files/Egger.Julian.2020.pdf
PB  - Oregon Health and Science University
PB  - Oregon Health and Science University
PY  - 2020
ID  - 8743
L4  - https://digitalcollections.ohsu.edu/record/8743/files/Egger.Julian.2020.pdf
KW  - Genomics
KW  - Alternative Splicing
KW  - acute myeloid leukemia
KW  - rna-sequencing
KW  - bioinformatics
TI  - Network-based alternative splicing signatures of drug response in AML
Y1  - 2020
L2  - https://digitalcollections.ohsu.edu/record/8743/files/Egger.Julian.2020.pdf
LK  - https://digitalcollections.ohsu.edu/record/8743/files/Egger.Julian.2020.pdf
UR  - https://digitalcollections.ohsu.edu/record/8743/files/Egger.Julian.2020.pdf
ER  -