TY  - GEN
N2  - Formation of a hemostatic clot is essential for minimizing blood loss upon injury and is mediated, in part, by tightly regulated activity of and crosstalk between platelets and plasma proteases of blood coagulation. Dysregulation of this otherwise protective clotting mechanism provokes thrombosis, which is caused by pathologic intravascular progression of some hemostatic mechanisms, and manifests as the common underlying pathology of major cardiovascular diseases. There remains an unmet clinical need for safer therapeutics that are effective while also preserving hemostasis. The present research defines signaling mechanisms underlying the role of platelet and coagulation proteases in hemostasis and vascular inflammation.
DO  - 10.6083/vm40xs28m
DO  - DOI
AB  - Formation of a hemostatic clot is essential for minimizing blood loss upon injury and is mediated, in part, by tightly regulated activity of and crosstalk between platelets and plasma proteases of blood coagulation. Dysregulation of this otherwise protective clotting mechanism provokes thrombosis, which is caused by pathologic intravascular progression of some hemostatic mechanisms, and manifests as the common underlying pathology of major cardiovascular diseases. There remains an unmet clinical need for safer therapeutics that are effective while also preserving hemostasis. The present research defines signaling mechanisms underlying the role of platelet and coagulation proteases in hemostasis and vascular inflammation.
T1  - Platelet signaling in hemostasis and vascular inflammation
DA  - 2021
AU  - Ngo, Anh
L1  - https://digitalcollections.ohsu.edu/record/8759/files/Ngo.Anh.2021.pdf
PB  - Oregon Health and Science University
PY  - 2021
ID  - 8759
L4  - https://digitalcollections.ohsu.edu/record/8759/files/Ngo.Anh.2021.pdf
KW  - Inflammation
KW  - Blood Coagulation
KW  - Blood Platelets
KW  - Thrombosis
KW  - Hemostasis
KW  - Atherosclerosis
TI  - Platelet signaling in hemostasis and vascular inflammation
Y1  - 2021
L2  - https://digitalcollections.ohsu.edu/record/8759/files/Ngo.Anh.2021.pdf
LK  - https://digitalcollections.ohsu.edu/record/8759/files/Ngo.Anh.2021.pdf
UR  - https://digitalcollections.ohsu.edu/record/8759/files/Ngo.Anh.2021.pdf
ER  -